Key learning objectives:
• Evaluating patients with coagulopathy in intensive care
• Managing coagulopathy in intensive care
• Understand the complications and limitations of various therapies
Walsh TS, Stanworth SJ, Prescott RJ, Lee RJ, Watson DM, Wyncoll D, et al. Prevalence, management, and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units. Crit Care Med. 2010;38(10):1939–1946.
Kolev K, Longstaff C. Bleeding related to disturbed fibrinolysis. Br J Haematol. 2016;175(1):12–23.
Tosetto A, Rodeghiero F, Castaman G, Goodeve A, Federici AB, Batlle J, et al. A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost. 2006;4(4):766–773.
Bonhomme F, Ajzenberg N, Schved JF, Molliex S, Samama CM, French A, et al. Pre-interventional haemostatic assessment: Guidelines from the French Society of Anaesthesia and Intensive Care. Eur J Anaesthesiol. 2013;30(4):142–162.
Committee on S, Practice P, Apfelbaum JL, Connis RT, Nickinovich DG, American Society of Anesthesiologists Task Force on Preanesthesia E, et al. Practice advisory for preanesthesia evaluation: an updated report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation. Anesthesiology. 2012;116(3):522–538.
Chee YL, Crawford JC, Watson HG, Greaves M. Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology. Br J Haematol. 2008;140(5):496–504.
Kotru M, Mutereja D, Purohit A, Tyagi S, Mahapatra M, Saxena R, et al. Mild Bleeders: Diagnosis is Elusive in Large Number of Patients. Mediterr J Hematol Infect Dis. 2016;8(1):e2016049.
Moenen F, Nelemans PJ, Schols SEM, Schouten HC, Henskens YMC, Beckers EAM. The diagnostic accuracy of bleeding assessment tools for the identification of patients with mild bleeding disorders: A systematic review. Haemophilia. 2018;24(4):525–535.
Bonhomme F, Boehlen F, Clergue F, de Moerloose P. Preoperative hemostatic assessment: a new and simple bleeding questionnaire. Can J Anaesth. 2016;63(9):1007–1015.
Faraoni D, Hardy JF, Van der Linden P. An early, multimodal, goal-directed approach of coagulopathy in the bleeding traumatized patient. Curr Opin Anaesthesiol. 2013;26(2):193–195.
Muller MC, de Jonge E, Arbous MS, Spoelstra-de Man AM, Karakus A, Vroom MB, et al. Transfusion of fresh frozen plasma in non-bleeding ICU patients--TOPIC trial: study protocol for a randomized controlled trial. Trials. 2011;12:266.
Chowdary P, Saayman AG, Paulus U, Findlay GP, Collins PW. Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol. 2004;125(1):69–73.
Shen L, Tabaie S, Ivascu N. Viscoelastic testing inside and beyond the operating room. J Thorac Dis. 2017;9(Suppl 4):S299-S308.
Mohamed M, Majeske K, Sachwani GR, Kennedy K, Salib M, McCann M. The impact of early thromboelastography directed therapy in trauma resuscitation. Scand J Trauma Resusc Emerg Med. 2017;25(1):99.
Sniecinski RM, Levy JH. Bleeding and management of coagulopathy. J Thorac Cardiovasc Surg. 2011;142(3):662–667.
Curry N, Foley C, Wong H, Mora A, Curnow E, Zarankaite A, et al. Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial. Crit Care. 2018;22(1):164.
Medow JE, Dierks MR, Williams E, Zacko JC. The emergent reversal of coagulopathies encountered in neurosurgery and neurology: a technical note. Clin Med Res. 2015;13(1):20–31.