VOLUME 24 , ISSUE 12 ( December, 2020 ) > List of Articles
Citation Information : Sepsis: An Evolutionary Perspective (Sepsis through the Eyes of a Microbe vs Clinical Sepsis through the Eyes of an Intensivist). Indian J Crit Care Med 2020; 24 (12):1165-1168.
DOI: 10.5005/jp-journals-10071-23670
License: CC BY-NC 4.0
Published Online: 20-02-2021
Copyright Statement: Copyright © 2020; The Author(s).
“Change of gene frequency in population” is the most fundamental concept of evolutionary biology. Human sepsis is a quantitative biological war between microbial genes and human genes, fought through their respective phenotypes. The prize of this war is an increase of gene frequency. Stating that sepsis is caused by a dysregulated host response is missing one half of the septic syndrome. Clinicians may gain a different perspective into the many intricacies of sepsis by conceptualizing it as an adaptive evolutionary process, rather than an abnormal physiological state. Clinicians may also get a deeper perspective by seeing it as a genotypic evolutionary process of natural selection rather than a phenotypic pathophysiological event.
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