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VOLUME 24 , ISSUE 5 ( May, 2020 ) > List of Articles


Therapeutic Plasma Exchange in Parvovirus B19-induced Acute Hepatic Failure

Dhirendra P Singh, Sheetal Agarwal, Ruby Singh, Devki Nandan, Anubhav Gupta

Keywords : Hepatic encephalopathy, Hepatic failure, Plasma exchange

Citation Information : Singh DP, Agarwal S, Singh R, Nandan D, Gupta A. Therapeutic Plasma Exchange in Parvovirus B19-induced Acute Hepatic Failure. Indian J Crit Care Med 2020; 24 (5):361-362.

DOI: 10.5005/jp-journals-10071-23421

License: CC BY-NC 4.0

Published Online: 28-07-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Parvovirus B19 has rarely been associated with acute liver failure (ALF), which has a high mortality. Plasma exchange that usually acts as a bridge to liver transplantation removes toxins, antibodies, cytokines, and can correct coagulopathy while maintaining a euvolemic state. Pediatric data regarding its use are scarce. We report a case of 16-year-old girl with acute liver failure in stage 4 encephalopathy with coagulopathy due to parvovirus B19 who was successfully managed with high-volume therapeutic plasma exchange (TPE). We tried to use it as a treatment modality due to nonavailability of in-hospital transplant facilities. Parvovirus B19 may be an underdiagnosed cause of acute viral hepatitis. Therapeutic plasma exchange can act as a bridge to liver transplant (LT) or bridge to recovery especially in self-limiting illnesses such as viral hepatitis.

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