Citation Information :
Deshmukh T, Varma A, Damke S, Meshram R. Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital. Indian J Crit Care Med 2020; 24 (8):701-704.
Aims and objectives: Utility of pediatric logistic organ dysfunction-2 (PELOD-2) score on day 1 within 1 hour of admission in predicting mortality in children admitted in pediatric intensive care unit (PICU). Background: Various scoring systems aid to evaluate the patient's mortality risk in the intensive care unit (ICU) by assigning a score and predicting the outcome. Critically ill children are characterized by large variations in the normal body homeostasis. These variations can be estimated by the change of the physiological variables from the normal range. Various scores are constructed from deviations of these changed variables. One such score, the PELOD-2 score, is used to predict mortality of patients admitted in PICU. Materials and methods: This study was carried out at a tertiary care center in central India to study the utility of PELOD-2 score within 1 hour of admission to predict mortality in patients admitted in PICU. Results: Total 129 patients were included in this study with mean age of 67 months. The system with highest admission was central nervous system with 42 children and 16.6% mortality, whereas those 7 patients with hematological system involvement had highest mortality of 28.5%. The mortality rate was 15.55%. In our study for PELOD-2 within 24 hours of admission, the area under receiver operating curve was 0.87 and the Hosmer–Lemeshow test was p = 0.42. Conclusion: Pediatric logistic organ dysfunction-2 score in our study had significant association with mortality along with the Hosmer–Lemeshow goodness-of-fit test showing a good prediction of mortality.
Bhadoria P, Bhagwat AG. Severity scoring systems in paediatric intensive care units. Indian J Anaesth 2008;52(Suppl 5):663–675.
Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F. Groupe francophone de réanimation et d′Urgences pédiatriques (GFRUP). PELOD-2: an update of the pediatric logistic organ dysfunction score. Crit Care Med 2013;41(7):1761–1773. DOI: 10.1097/CCM.0b013e31828a2bbd.
Marcin JP, Song J, Leigh JP. The impact of pediatric intensive care unit volume on mortality: a hierarchical instrumental variable analysis. Pediatr Crit Care Med 2005;6(2):136–141. DOI: 10.1097/01.PCC.0000154962.73861.66.
Leteurtre S, Grandbastien B, Leclerc F, Parslow R. Groupe francophone de réanimation et urgences pédiatriques, paediatric intensive care audit network. international comparison of the performance of the paediatric index of mortality (PIM) 2 score in two national data sets. Intensive Care Med 2012;38(8):1372–1380. DOI: 10.1007/s00134-012-2580-6.
Thukral A, Kohli U, Lodha R, Kabra SK, Arora NK. Validation of the PELOD score for multiple organ dysfunction in children. Indian Pediatr 2007;44(9):683.
Patki VK, Raina S, Antin JV. Comparison of severity scoring systems in a pediatric intensive care unit in India: a single-center prospective, observational cohort study. J Pediat Intensive Care 2017;6(02):098–102.
El-Nawawy A, Mohsen AA, Abdel-Malik M, Taman SO. Performance of the pediatric logistic organ dysfunction (PELOD) and (PELOD-2) scores in a pediatric intensive care unit of a developing country. Eur J Pediatr 2017;176(7):849–855.
Zhong M, Huang Y, Li T, Xiong L, Lin T, Li M, et al. Day-1 PELOD-2 and day-2 scores in children with sepsis in the PICU. J Pediatr (Rio J) 2019. DOI: 10.1016/j.jped.2019.07.007.
Jat KR, Jhamb U, Gupta VK. Serum lactate levels as the predictor of outcome in pediatric septic shock. Indian J Crit Care Med 2011;15(2):102.
Hosmer DW, Hosmer T, Le Cessie S, Lemeshow S. A comparison of goodness-of-fit tests for the logistic regression model. Statist Med 1997;16(9):965–980.
Rady HI, Mohamed SA, Mohssen NA, ElBaz M. Application of different scoring systems and their value in pediatric intensive care unit. Egyptian Pediatric Association Gazette 2014;62(3-4):59–64.
Meakins J, Long CN. Oxygen consumption, oxygen debt and lactic acid in circulatory failure. J Clin Invest 1927;4(2):273–293. DOI: 10.1172/JCI100123.
Ramazani J, Hosseini M. Comparison of the predictive ability of the pediatric risk of mortality III, pediatric index of mortality, and pediatric logistic organ dysfunction in medical and surgical intensive care units. J Compr Ped 2019;10(2):e82830. DOI: 10.5812/compreped.82830.
Varma A, Damke S, Meshram R, Vagha J, Kher A, Vagha K. Prediction of mortality by pediatric risk of mortality (PRISM III) score in tertiary care rural hospital in India. Int J Contemp Pediatr 2017;4(2):322–331. DOI: 10.18203/2349-3291.ijcp20170003.
Mathews S, Rajan A, Soans ST. Prognostic value of rise in neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting the mortality in paediatric intensive care. Int J Contemp Pediat 2019;6(3):1052–1058. DOI: 10.18203/2349-3291.ijcp20191044.
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, et al. Performance of the pediatric logistic organ dysfunction-2 score in critically ill children requiring plasma transfusions. Ann Intensive Care 2016;6(1):98. DOI: 10.1186/s13613-016-0197-6Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053948/.
Hamshary AAEE, Sherbini SAE, Elgebaly HF, Amin SA. Prevalence of multiple organ dysfunction in the pediatric intensive care unit: pediatric risk of mortality III versus pediatric logistic organ dysfunction scores for mortality prediction. Prevalência da falência de múltiplos órgãos na unidade de terapia intensiva pediátrica: comparação dos escores pediatric risk of mortality III e pediatric logistic organ dysfunction para predição de mortalidade. Rev Bras Ter Intensiva 2017;29(2):206–212. DOI: 10.5935/0103-507X.20170029.
Leclerc F, Duhamel A, Deken V, Grandbastien B, Leteurtre S. Pédiatriques (GFRUP) on behalf of the GF de R et U. Can the pediatric logistic organ Dysfunction-2 score on day 1 be used in clinical criteria for sepsis in children?*. Pediat Crit Care Med 2017;18(8):758–763. DOI: 10.1097/PCC.0000000000001182.
Schlapbach LJ, Straney L, Bellomo R, MacLaren G, Pilcher D. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med 2018;44(2):179–188. DOI: 10.1007/s00134-017-5021-8.