SEARCH WITHIN CONTENT
VOLUME 25 , ISSUE 1 ( January, 2021 ) > List of Articles
Vikas Bhagat, Rahul A Pandit, Shwetha Ambapurkar, Manju Sengar
Keywords : Antimicrobials, Calcineurin inhibitors, Corticosteroids, Drug–drug interaction, Immunosuppressants, Intravenous immunoglobulin, Monoclonal antibodies, mTOR inhibitors, Solid organ transplant
Citation Information : Bhagat V, Pandit RA, Ambapurkar S, Sengar M. Drug Interactions between Antimicrobial and Immunosuppressive Agents in Solid Organ Transplant Recipients. Indian J Crit Care Med 2021; 25 (1):67-76.
License: CC BY-NC 4.0
Published Online: 18-01-2021
Copyright Statement: Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.
The number of allogeneic solid organ and bone marrow transplants is increasing all over the world. To prevent transplant rejection and treat acute rejection of transplant, immunosuppressant drugs are used. The outcomes of solid organ transplants have dramatically improved over last 30 years, due to availability of multiple immunosuppressive agents, with varied mechanisms of action. The use of intense immunosuppression makes the individual having undergone solid organ transplant at the risk of several serious infections, which may prove fatal. To prevent and treat these infections (when they occur), patients are often given antimicrobial prophylaxis and therapy. The use of antimicrobials can interfere with the metabolism of the immunosuppressants, and may put the patient at risk of developing severe adverse effects due to unwanted increase or decrease in the serum levels of immunosuppressive agents. Knowledge of these interactions is essential for successful management of solid organ transplant patients. We therefore decided to review the literature and present the interactions that commonly occur between these two life-saving groups of drugs.
© Jaypee Brothers Medical Publishers (P) LTD.