Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 25 , ISSUE 2 ( February, 2021 ) > List of Articles

CASE SERIES

Neurological Manifestations of COVID-19: A Series of Seven Cases

Kavya Goel, Harish C Sachdeva, Saurav M Mustafi

Citation Information : Goel K, Sachdeva HC, Mustafi SM. Neurological Manifestations of COVID-19: A Series of Seven Cases. Indian J Crit Care Med 2021; 25 (2):219-223.

DOI: 10.5005/jp-journals-10071-23723

License: CC BY-NC 4.0

Published Online: 01-02-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Identification of neurological manifestations associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) in patients with no or mild pulmonary infection proves to be a challenge. The incidence of neurological associations of COVID-19 may be small as compared with respiratory disease; however, in the present scenario with an increasing number of cases each day, the overall incidence of patients with neurological manifestations and their health-related socioeconomic impact might be large. Hence it is important to report such cases so that healthcare providers and concerned authorities are aware of and may prepare for the growing burden. The literature on primary neurological manifestations of COVID-19 is limited, and hence our case series is relevant in the current scenario. The most commonly reported neurological complications are cerebrovascular accidents, encephalopathy, encephalitis, meningitis, and Guillain-Barré syndrome (GBS). We present a series of seven cases with various neurological presentations and possible complications from this novel virus infection.


HTML PDF Share
  1. Zu ZY, Jiang MD, Xu PP, Chen W, Ni QQ, Lu GM, et al. Coronavirus disease 2019 (COVID-19): a perspective from China. Radiology 2020;296(2):E15–E25. DOI: 10.1148/radiol.2020200490.
  2. Green A. Li Wenliang. Lancet 2020;395(10225):682. DOI: 10.1016/S0140-6736(20)30456-6.
  3. Guan W, Ni Z, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–1720. DOI: 10.1056/NEJMoa2002032.
  4. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun 2020;109:102433. DOI: 10.1016/j.jaut.2020.102433.
  5. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenk M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 2020;382(23):2268–2270. DOI: 10.1056/NEJMc2008597.
  6. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020;11(7):995–998. DOI: 10.1021/acschemneuro. 0c00122.
  7. Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 2020;9(1):45. DOI: 10.1186/s40249-020-00662-x.
  8. Kasal DA, De Lorenzo A, Tibiriçá E. COVID-19 and microvascular disease: pathophysiology of SARS-CoV-2 Infection with focus on the renin-angiotensin system. Heart Lung Circ 2020;29(11):1596–1602. DOI: 10.1016/j.hlc.2020.08.010 (Epub ahead of print).
  9. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-vessel stroke as a presenting feature of COVID-19 in the young. N Engl J Med 2020;382(20):e60. DOI: 10.1056/NEJMc2009787.
  10. Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry 2020;91(8):889–891. DOI: 10.1136/jnnp-2020-323586.
  11. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77(6):683–690. DOI: 10.1001/jamaneurol.2020.1127.
  12. Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain-Barré syndrome associated with SARS-CoV-2. N Engl J Med 2020;382(26):2574–2576. DOI: 10.1056/NEJMc2009191.
  13. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis 2020;94:55–58. DOI: 10.1016/j.ijid.2020.03.062.
  14. Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol 2020;19(5):383–384. DOI: 10.1016/S1474-4422(20)30109-5.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.