Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 25 , ISSUE 9 ( September, 2021 ) > List of Articles


Mucormycosis in COVID-19: Is Zinc a Silent Killer in India?

Sayan Nath

Keywords : COVID-19, Mucormycosis, Zinc

Citation Information : Nath S. Mucormycosis in COVID-19: Is Zinc a Silent Killer in India?. Indian J Crit Care Med 2021; 25 (9):1079-1080.

DOI: 10.5005/jp-journals-10071-23938

License: CC BY-NC 4.0

Published Online: 08-09-2021

Copyright Statement:  Copyright © 2021; The Author(s).


  1. Available at (accessed 23 May 2021).
  2. Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diab Metabol Syndr Clin Res Rev. 2021. DOI: 10.1016/j.dsx.2021.05.019.
  3. Prakash H, Chakrabarti A. Epidemiology of mucormycosis in India. Microorganisms 2021;9:523. DOI: 10.3390/microorganisms9030523.
  4. Gangneux JP, Bougnoux ME, Dannaoui E. Invasive fungal diseases during COVID-19: We should be prepared. J Mycol Med 2020;30(2):100971. DOI: 10.1016/j.mycmed.2020.100971.
  5. Thomas S, Patel D, Bittel B. Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial. JAMA Netw Open 2021;4(2):e210369. DOI: 10.1001/jamanetworkopen.2021.0369.
  6. COVID-19 Treatment Guidelines Panel. Coronavirus disease 2019 (COVID-19) treatment guidelines. National Institutes of Health. Available at: (accessed 23 May 2021).
  7. Management protocol for COVID-19. Available at: (accessed 23 May 2021).
  8. Revised guideline for home isolation/home care of COVID-19 positive patients. Municipal Corporation of Greater Mumbai. Available at: (accessed 23 May 2021).
  9. Wilson D. An evolutionary perspective on zinc uptake by human fungal pathogens. Metallomics 2015;7(6):979–985. DOI: 10.1039/c4mt00331d.
  10. Staats CC, Kmetzsch L, Schrank A, Vainstein MH. Fungal zinc metabolism and its connections to virulence. Front Cell Infect Microbiol 2013;3:65. DOI: 10.3389/fcimb.2013.00065.
  11. Lulloff SJ, Hahn BL, Sohnle PG. Fungal susceptibility to zinc deprivation. J Lab Clin Med 2004;144:208–214. DOI: 10.1016/j.lab.2004.07.007.
  12. Leonardelli F, Macedo D, Dudiuk C, Theill L, Cabeza MS, Gamarra S, et al. In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six mucorales species. Antimicrob Agents Chemother 2019;63(5):e00266. DOI: 10.1128/AAC.00266-19.
  13. Cohrt KAO, Marín L, Kjellerup L, Clausen JD, Dalby-Brown W, Calera JA, et al. Novel zinc-attenuating compounds as potent broad-spectrum antifungal agents with in vitro and in vivo efficacy. Antimicrob Agents Chemother 2018;62(5):e02024. DOI: 10.1128/AAC.02024-17.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.