Advances in Microcirculatory Assessment: A Game Changer in Sepsis Management or the Latest Fad?
Ruchi Gupta
Citation Information :
Gupta R. Advances in Microcirculatory Assessment: A Game Changer in Sepsis Management or the Latest Fad?. Indian J Crit Care Med 2022; 26 (3):261-263.
De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002;166(1):98–104. DOI: 10.1164/rccm.200109-016oc.
Monnet X, Saugel B. Could resuscitation be based on microcirculation data? We are not sure. Intensive Care Med 2018;44: 950–953. Available from: https://doi.org/10.1007/s00134-018-5180-2.
Bateman RM, Walley KR. Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care 2005;9(Suppl 4):S27–S32. DOI: 10.1186/cc3756.
Trzeciak S, McCoy JV, Phillip Dellinger R, et al. Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008;34(12):2210–2217. DOI: 10.1007/s00134-008-1193-6.
Skytte Larsson J, Krumbholz V, Enskog A, Bragadottir G, Redfors B, Ricksten SE. Renal Blood Flow, Glomerular Filtration Rate, and Renal Oxygenation in Early Clinical Septic Shock. Crit Care Med 2018;46(6):e560–e566. DOI: 10.1097/CCM.0000000000003088.
Dumas G, Lavillegrand JR, Joffre J, et al. Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters. Crit Care 2019;23(1):211. DOI: 10.1186/s13054-019-2496-4.
Kattan E, Hernández G, Ospina-Tascón G, Valenzuela ED, Bakker J, Castro R. ANDROMEDA-SHOCK Study Investigators and the Latin America Intensive Care Network (LIVEN). A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study. Ann Intensive Care 2020;10(1):114. DOI: 10.1186/s13613-020-00732-1.
Panda A, Revadi G, Sharma JP, Pakhare A, Singhai A, Joshi R, et al. On Admission, Microcirculation Abnormality is an Independent Predictor of Sepsis and Sepsis-related Mortality: A Hospital-based Study. Indian J Crit Care Med 2022;26(3):294–301.
Verdant CL, De Backer D, Bruhn A, et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med 2009;37(11):2875–2881. DOI: 10.1097/CCM.0b013e3181b029c1.
Ince C, Boerma EC, Cecconi M, et al. Cardiovascular Dynamics Section of the ESICM. Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. Intensive Care Med 2018;44(3):281–299. DOI: 10.1007/s00134-018-5070-7.
Trzeciak S, Dellinger RP, Parrillo JE, et al. Microcirculatory Alterations in Resuscitation and Shock Investigators. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007;49(1):88–98, 98.e1–e2. DOI: 10.1016/j.annemergmed.2006.08.021.
Ospina-Tascon G, Neves AP, Occhipinti G. Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med 2010;36(6):949–955. DOI: 10.1007/s00134-010-1843-3.
De Backer D, Creteur J, Dubois MJ, et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Critical Care Medicine 2006;34(2):403–408. DOI: 10.1097/01.ccm.0000198107.61493.5a.
Boerma EC, Koopmans M, Konijn A, et al. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med 2010;38(1):93–100. DOI: 10.1097/CCM.0b013e3181b02fc1.
Büchele GL, Silva E, Ospina-Tascón GA, Vincent JL, De Backer. Effects of hydrocortisone on microcirculatory alterations in patients with septic shock. Crit Care Med 2009;37(4):1341–1347. DOI: 10.1097/ccm.0b013e3181986647.
Ospina-Tascón GA, Umaña M, Bermúdez WF, Bautista-Rincón DF, Valencia JD, Madriñán HJ, et al. Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med 2016;42(2):211–221. DOI: 10.1007/s00134-015-4133-2. Epub 2015 Nov 17.
Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 2009;37(6):1961–1966. DOI: 10.1097/CCM.0b013e3181a00a1c.
Dubin A, Pozo MO, Casabella CA, et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care 2009;13(3):R92. DOI: 10.1186/cc7922.
