Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 26 , ISSUE 3 ( March, 2022 ) > List of Articles


Probiotics: Should We Use Them Proactively in Critical Illness?

Keywords : Critical illness, Dysbiosis, Intensive care units, Probiotics, Systematic review, Umbrella review, Ventilator-associated pneumonia

Citation Information : Probiotics: Should We Use Them Proactively in Critical Illness?. Indian J Crit Care Med 2022; 26 (3):266-267.

DOI: 10.5005/jp-journals-10071-24174

License: CC BY-NC 4.0

Published Online: 30-03-2022

Copyright Statement:  Copyright © 2022; The Author(s).


  1. Pirracchio R, Gropper MA. Heterogeneity in intensive care: low severity does not mean low risk! Anesthesiology 2019;130(2):190–191. DOI: 10.1097/ALN.0000000000002537.
  2. Santacruz CA, Pereira AJ, Celis E, Vincent J-L. Which multicenter randomized controlled trials in critical care medicine have shown reduced mortality? A systematic review. Crit Care Med 2019;47(12):1680–1691. DOI: 10.1097/CCM.0000000000004000.
  3. Wischmeyer PE, McDonald D, Knight R. Role of the microbiome, probiotics, and “dysbiosis therapy” in critical illness. Curr Opin Crit Care 2016;22(4):347–353. DOI: 10.1097/MCC.0000000000000321.
  4. Batra P, Soni KD, Mathur P. Efficacy of probiotics in the prevention of VAP in critically ill ICU patients: an updated systematic review and meta-analysis of randomized control trials. J Intensive Care 2020;8:81. DOI: 10.1186/s40560-020-00487-8.
  5. Madsen K. Probiotics in critically ill patients. J Clin Gastroenterol 2008;42 (Suppl 3) Pt 1:S116–S118. DOI: 10.1097/MCG.0b013e31817283cb.
  6. Theodorakopoulou M, Perros E, Giamarellos-Bourboulis EJ, Dimopoulos G. Controversies in the management of the critically ill: the role of probiotics. Int J Antimicrob Agents 2013;42 (Suppl): S41–S44. DOI: 10.1016/j.ijantimicag.2013.04.010.
  7. Naseri A, Seyedi-Sahebari S, Mahmoodpoor A, Sanaie S. Probiotics in Critically Ill Patients: An Umbrella Review. Indian J Crit Care Med 2022;26(3):339–360.
  8. Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, et al. Effect of probiotics on incident ventilator-associated pneumonia in critically ill patients: a randomized clinical trial. Journal of the American Medical Association 2021;326(11):1024–1033. DOI: 10.1001/jama.2021.13355.
  9. Foroutan F, Guyatt G, Alba AC, Ross H. Meta-analysis: mistake or milestone in medicine? Heart 2018;104(19):1559–1561. DOI: 10.1136/heartjnl-2018-313042.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.