Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 26 , ISSUE 6 ( June, 2022 ) > List of Articles

CASE REPORT

Porphyria-induced Postpartum Reversible Posterior Encephalopathy Syndrome

Shri R Sharma, Nalini Sharma, Baiakmenlang Synmon, Yasmeen Hynniewtaya

Keywords : Acute intermittent porphyria, Encephalopathy, Postpartum period, Seizures

Citation Information : Sharma SR, Sharma N, Synmon B, Hynniewtaya Y. Porphyria-induced Postpartum Reversible Posterior Encephalopathy Syndrome. Indian J Crit Care Med 2022; 26 (6):728-730.

DOI: 10.5005/jp-journals-10071-24253

License: CC BY-NC 4.0

Published Online: 20-06-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Acute intermittent porphyria (AIP) is a rare condition that needs to be kept in mind where its early recognition, conservative management, and removal of the precipitating factor are the key factors in its management. This “little imitator” presented with varied symptoms is often misdiagnosed. The diagnosis requires a strong index of suspicion as choosing an antiepileptic medication in the management of seizure requires a judicial choice to avoid precipitation of the underlying illness.


PDF Share
  1. Kumari DS, Murthy NLN, Reddy SK, Duvvuru NS, Motor R. Acute intermittent Porphyria presenting with posterior reversible encephalopathy syndrome: a rare cause of abdominal pain and seizures. Indian J Crit Care Med 2020;24(8):724–726. DOI: 10.5005/jp-journals-10071-23532.
  2. Bonkovsky HL, Maddukuri VC, Yazici C, Anderson KE, Bissell DM, Bloomer JR, et al. Acute porphyrias in the USA: features of 108 subjects from porphyria consortium. Am J Med 2014;127(12):1233–1241. DOI: 10.1016/j.amjmed.2014.06.036.
  3. Lakhotia M, Pahadiya HR, Singh J, Bhansali S, Choudhary S, Jangid H. Posterior reversible encephalopathy syndrome as a rare presenting feature of acute intermittent porphyria. Neurol India 2015;63(4): 607–609. DOI: 10.4103/0028-3886.162081.
  4. Pedraza R, Marik P, Varon P. Posterior reversible encephalopathy syndrome. Crit Care Shock 2009;12:135–143.
  5. Dagnes A, Gilhooley MJ. Acute intermittent porphyria leading to posterior reversible encephalopathy syndrome (PRES): a rare cause of abdominal pain and seizures. BMJ Case Rep 2016;2016: bcr2016215350. DOI: 10.1136/bcr-2016-215350.
  6. Sandra T, Naiade C, Caroline M, Gabriel F, Caroline B, Osvaldo N. Acute intermittent porphyria associated with reversible posterior encephalopathy syndrome: a rare presentation (1804). Neurology 2020;94(15 Supplement).
  7. Jaramilo-carlle DA, Solano JM, Rabinstein AA, Bonkovsky HL. Porphyria-induced posterior reversible encephalopathy syndrome and central nervous system dysfunction. Mol Gene Metab 2019;128(3):242–253. DOI: 10.1016/j.ymgme.2019.10.011.
  8. Tomar GS, Sethi S, Kriplani TC, Narang N. Post partum acute intermittent porphyria: a case report. Indian Anaesth form 2010.
  9. Duan Y, Kang S, Zhao J, Tang Z. Reversible posterior encephalopathy syndrome in patient with acute intermittent porphyrin: a case report. Int J Womens Health Wellness 2017;3(2):52. DOI: 10.23937/2474-1353/1510052.
  10. Zheng X, Liu X, Wang Y, Zhao R, Qu L, Pei H, et al. Acute discontinuous porphyria presenting with seizures and posterior reversible encephalopathy syndrome. Medicine 2018;97:36:e11665. http://dx.doi.org/10.1097/MD.0000000000011665.
  11. Mehta M, Rath GP, Pandey UP, Marda M, Mahajan C, Dash HH. Intensive care management of patients with acute intermittent porphyria: clinical report of four cases and review of literature. Indian J Crit Care Med 2010;14(2):88–91. DOI: 10.4103/0972-5229.68222.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.