Citation Information :
Makhlouf A, Peipoch L, Duport P, Darrieux E, Reguerre Y, Ramful D, Alessandri J, Levy Y. First Case of Acute Myocarditis Caused by Metapneumovirus in an Immunocompromised 14-year-old Girl. Indian J Crit Care Med 2022; 26 (6):745-747.
Background: Human metapneumovirus (hMPV) is a paramyxovirus, well known as a causative agent of respiratory tract infections. Non-respiratory manifestations, including cardiac impairments, remain rare. Only two cases of myocarditis caused by hMPV have been described in adults.
Case description: We present the case of a 14-year-old female suffering from Burkitt leukemia and diagnosed with severe myocarditis caused by hMPV, based on results from real-time polymerase chain reaction (RT-PCR) and magnetic resonance imaging (MRI). She was successfully treated by venoarterial extracorporeal membrane oxygenation and intravenous immunoglobulins. She was discharged from pediatric intensive care unit (PICU) 3 weeks later.
Conclusion: This is the first pediatric case of hMPV myocarditis requiring venoarterial extracorporeal membrane oxygenation.
Panda S, Mohakud NK, Pena L, Kumar S. Human metapneumovirus: review of an important respiratory pathogen. Int J Infect Dis 2014;25:45–52. DOI: 10.1016/j.ijid.2014.03.1394.
Bejiqi R, Retkoceri R, Maloku A, Mustafa A, Bejiqi H, Bejiqi R. The diagnostic and clinical approach to pediatric myocarditis: a review of the current literature. Open Access Maced J Med Sci 2019;7(1):162–173. DOI: 10.3889/oamjms.2019.010.
van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001;7(6):719–724. DOI: 10.1038/89098.
Choi MJ, Song JY, Yang TU, Jeon JH, Noh JY, Hong KW, et al. Acute myopericarditis caused by human metapneumovirus. Infect Chemother 2016;48(1):36–40. DOI: 10.3947/ic.2016.48.1.36.
Weinreich MA, Jabbar AY, Malguria N, Haley RW. New-onset myocarditis in an Iimunocompetent adult with acute metapneumovirus infection. Case Rep Med 2015;2015:814269. DOI: 10.1155/2015/814269.
Yakut K, Varan B, Erdoğan İ, Tokel KÇ. Acute respiratory distress syndrome and myocarditis caused by human metapneumovirus in a child. Bezmialem Science 2020;8(2):212–214. DOI: 10.14235/bas.galenos.2020.3919.
Zamorano JL, Lancellotti P, Muñoz DR, Aboyans V, Asteggiano R, Galderisi M, et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines. Kardiol Pol 2016;74(11):1193–1233. DOI: 10.5603/KP.2016.0156.
Finet JE, Tang WHW. Protecting the heart in cancer therapy. F1000 Res 2018;7:F1000. DOI: 10.12688/f1000research.15190.1.
Maisch B, Alter P. Treatment options in myocarditis and inflammatory cardiomyopathy: Focus on i. v. immunoglobulins. Herz 2018;43(5): 423–430. DOI: 10.1007/s00059-018-4719-x.
Robinson J, Hartling L, Vandermeer B, Klassen TP. Intravenous immunoglobulin for presumed viral myocarditis in children and adults. Cochrane Database Syst Rev 2015;(5):CD004370. DOI: 10.1002/14651858.CD004370.pub3.
Huang X, Sun Y, Su G, Li Y, Shuai X. Intravenous immunoglobulin therapy for acute myocarditis in children and adults: a meta-analysis. Int Heart J 2019;60(2):359–365. DOI: 10.1536/ihj.18-299.