Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 27 , ISSUE 5 ( May, 2023 ) > List of Articles


Serum Procalcitonin vs SOFA Score in Predicting Outcome in Sepsis Patients in Medical Intensive Care Unit

Vikrant Vijaykumar Shinde, Aman Jha, Meenakshi Sundari Subramaniyan Natarajan, Vrinda Vijayakumari, Gopikrishna Govindaswamy, Shriranjini Sivaasubramani, Rajeswari Kapaleechwaran Balakrishnan

Keywords : Sepsis, Septic shock, Serum procalcitonin, SOFA score

Citation Information : Shinde VV, Jha A, Natarajan MS, Vijayakumari V, Govindaswamy G, Sivaasubramani S, Balakrishnan RK. Serum Procalcitonin vs SOFA Score in Predicting Outcome in Sepsis Patients in Medical Intensive Care Unit. Indian J Crit Care Med 2023; 27 (5):348-351.

DOI: 10.5005/jp-journals-10071-24462

License: CC BY-NC 4.0

Published Online: 29-04-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Background: Sepsis is a dysregulated host response to infection that leads to acute organ dysfunction. The Sequential Organ Failure Assessment (SOFA) score is one of the gold standard tests in assessing the patient's status during ICU stay and also to predict the clinical outcomes of the patients. Procalcitonin (PCT) is a more specific marker for bacterial infection. In this study, we compared PCT and SOFA scores in predicting morbidity and mortality outcomes in sepsis. Materials and methods: A prospective cohort study was conducted on 80 patients with suspected sepsis. Patients who were >18 years of age with suspected sepsis presenting to the emergency room within 24–36 hours of illness are included in the study. SOFA score was calculated, and blood was drawn for PCT at the time of admission. Results: The average SOFA score in survivors was 6.1 ± 1.93, whereas, in nonsurvivors, it was 8.3 ± 2.13. The average PCT level in survivors was 3.7 ± 1.5, whereas, in nonsurvivors, was 6.4 ± 3.13. Area under the curve (AUC) for serum procalcitonin was found to be 0.77 (p value = 0.001) with average procalcitonin level of 4.15 ng/mL with sensitivity of 70% and specificity of 60%. AUC of SOFA score was found to be 0.78 (p value = 0.001) with an average score of 8, having a sensitivity of 73% and specificity of 74%. Conclusion: Serum PCT and SOFA scores are significantly elevated in patients with sepsis and septic shock, indicating their utility in predicting the severity and also their ability to assess end-organ damage.

PDF Share
  1. Brant EB, Seymour CW, Angus DC. Harrison's Principles of Internal Medicine, 21st edition, McGraw Hill LLC; 2022. pp. 2241–2242.
  2. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315(8):801–810. DOI: 10.1001/jama.2016.0287.
  3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy collaborative group. Early goal-directed therapy in the septic shock. N Engl J Med 2001;345(19):1368–1377. DOI: 10.1056/NEJMoa010307. PMID:11794169.
  5. Chintamani A, Prakash B, Abraham BK. Incidence and impact of healthcare-associated infections on patients primarily admitted with sepsis and non-sepsis diagnoses. Indian J Crit Care Med 2021;25(3):292–295. DOI: 10.5005/jp-journals-10071-23760.
  7. Demitral T, Sen P, Nemli SA. Diagnostic value of procalcitonin in predicting bacteremia in intensive care unit. Indian J Crit Care Med 2018;22(2):78–84. DOI: 10.4103/ijccm.IJCCM_437_17.
  8. Samsudin I, Vasikaran SD. Clinical utility and measurement of procalcitonin. Clin Biochem Rev 2017;38(2): 59–68. PMCID: PMC5759088.
  9. Mayr FB, Yendi S, Angus DC. Epidemiology of severe sepsis. Virulence 2014;5(1):4–11. DOI: 10.4161/viru.27372.
  10. Chatterjee S, Bhattacharya M, Todi SK. Epidemiology of adult-population sepsis in India: A single centre 5 year experience. Indian J Crit Care Med 2017;21(9):573-577. DOI: 10.4103/ijccm.IJCCM_240_17.
  11. Koch GCKW, Peacock SJ, van der Poll T, Wiersema WJ. The impact of diabetes on the pathogenesis of sepsis. Eur J Clin Microbiol Infect Dis 2012;31(4):379–388. DOI: 10.1007/s10096-011-1337-4.
  12. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993;341(8844):515–518. DOI: 10.1016/0140-6736(93)90277-n.
  13. Annam V, Maaledu P, Bhaskar MV, Venugopal L. Evaluation of serum procalcitonin and SOFA score in assessing the outcome in sepsis. Int J Sci Study 2016;3(10):48–51. DOI: 10.17354/ijss/2016/10.
  14. Vijayan AL, Vanimaya, Ravindran S, Saikant S, Lakshmi S, Kartik R, et al. Procalcitonin: A promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care 2017; 5: 51. DOI: 10.1186/s40560-017-0246-8.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.