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VOLUME 27 , ISSUE 7 ( July, 2023 ) > List of Articles


Early Antibiotics in Septic Shock: A Desirable Goal but “Curb Your Enthusiasm”

Ashit Hegde

Keywords : Antibiotics, Guidelines, Intensive care unit, Sepsis bundles, Septic shock

Citation Information : Hegde A. Early Antibiotics in Septic Shock: A Desirable Goal but “Curb Your Enthusiasm”. Indian J Crit Care Med 2023; 27 (7):459-460.

DOI: 10.5005/jp-journals-10071-24494

License: CC BY-NC 4.0

Published Online: 30-06-2023

Copyright Statement:  Copyright © 2023; The Author(s).


  1. Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med 2014;42(8):1749–1755. DOI: 10.1097/CCM.0000000000000330.
  2. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589–1596. DOI: 10.1097/01.CCM.0000217961.75225.E9.
  3. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock 2021;Intensive Care Med 2021;47(11):1181–1247. DOI: 10.1007/s00134-021-06506-y.
  4. Machado FR, Ferreira EM, Schippers P, de Paula IC, Saes LSV, de Oliveira FI, et al. Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results. Crit Care 2017;21(1):268. DOI: 10.1186/s13054-017-1858-z.
  5. Medeiros DNM, Shibata AO, Pizarro CF, Rosa MLA, Cardoso MP, Troster EJ. Barriers and proposed solutions to a successful implementation of pediatric sepsis protocols. Front Pediatr 2021;9:755484. DOI: 10.3389/fped.2021.755484.
  6. Moraes RB, Haas JS, Vidart J, Nicolaidis R, Deutschendorf C, Moretti MMS, et al. A coordinated and multidisciplinary strategy can reduce the time for antibiotics in septic patients at a university hospital. Indian J Crit Care Med 2023;27(7):465–469.
  7. IDSA Sepsis Task force. IDSA Position Statement: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines. Clin Infect Dis 2018;66(10):1631–1635. DOI: 10.1093/cid/cix997.
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