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VOLUME 27 , ISSUE 9 ( September, 2023 ) > List of Articles


Sepsis Induced Coagulopathy – Bringing Science to the Bedside

Srinivas Samavedam

Keywords : Disseminated intravascular coagulation, Rotational thromboelastometry, Sepsis, Sepsis induced coagulopathy, Thromboelastogram, Viscoelastic

Citation Information : Samavedam S. Sepsis Induced Coagulopathy – Bringing Science to the Bedside. Indian J Crit Care Med 2023; 27 (9):611-612.

DOI: 10.5005/jp-journals-10071-24537

License: CC BY-NC 4.0

Published Online: 31-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


  1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315(8):801–810. DOI: 10.1001/jama.2016.0287.
  2. Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet 2018;392(10141):75–87. DOI: 10.1016/S0140-6736(18)30696-2.
  3. Levi M, van der Poll T. Coagulation and sepsis. Thromb Res 2017;149:38–44. DOI: 10.1016/j.thromres.2016.11.007.
  4. Giustozzi M, Ehrlinder H, Bongiovanni D, Borovac JA, Guerreiro RA, Gasecka A, et al. Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment. Blood Rev 2021;50:100864. DOI: 10.1016/j.blre.2021.100864.
  5. Sungurlu S, Kuppy J, Balk RA. Role of antithrombin III and tissue factor pathway in the pathogenesis of sepsis. Crit Care Clin 2020;36(2):255–265. DOI: 10.1016/j.ccc.2019.12.002.
  6. Petros S, Kliem P, Siegemund T, Siegemund R. Thrombin generation in severe sepsis. Thromb Res 2012;129(6):797–800. DOI: 10.1016/j.thromres.2011.08.004.
  7. Iba T, Ito T, Maruyama I, Jilma B, Brenner T, Müller MC, et al. Potential diagnostic markers for disseminated intravascular coagulation of sepsis. Blood Rev 2016;30(2):149–155. DOI: 10.1016/j.blre.2015.10.002.
  8. Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: Incidence, risk factors, and its association with clinical outcome. J Intensive Care 2013;30(1):9. DOI: 10.1186/2052-0492-1-9.
  9. Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000;28(6):1871–1876. DOI: 10.1097/00003246-200006000-00031.
  10. Semeraro F, Ammollo CT, Caironi P, Masson S, Latini R, Panigada M, et al. Low D-dimer levels in sepsis: Good or bad? Thromb Res 2019;174:13–15. DOI:
  11. Favresse J, Lippi G, Roy PM, Chatelain B, Jacqmin H, Ten Cate H, et al. D-Dimer: Preanalytical, analytical, postanalytical variables, and clinical applications. Crit Rev Clin Lab Sci 2018;55(8):548–577. DOI: 10.1080/10408363.2018.1529734.
  12. Scarlatescu E, Juffermans NP, Thachil J. The current status of viscoelastic testing in septic coagulopathy. Thromb Res 2019;183:146–152. DOI: 10.1016/j.thromres.2019.09.029.
  13. Georgiadou P, Sokou R, Tsantes AG, Parastatidou S, Konstantinidi A, Houhoula D, et al. The non-activated thromboelastometry (natem) assay's application among adults and neonatal/pediatric population: A systematic review. Diagnostics (Basel) 2022;12(3):658. DOI: 10.3390/diagnostics12030658.
  14. Müller MC, Meijers JC, Vroom MB, Juffermans NP. Utility of thromboelastography and/or thromboelastometry in adults with sepsis: A systematic review. Crit Care 2014;18(1):R30. DOI: 10.1186/cc13721.
  15. Adamik B, Gozdzik W, Jakubczyk D, Welna M, Kübler A. Coagulation abnormalities identified by thromboelastometry in patients with severe sepsis: The relationship to endotoxemia and mortality. Blood Coagul Fibrinolysis 2017;28(2):163–170. DOI: 10.1097/MBC.0000000000000572.
  16. Kim SM, Kim SI, Yu G, Kim JS, Hong SI, Chae B, et al. Role of thromboelastography as an early predictor of disseminated intravascular coagulation in patients with septic shock. J Clin Med 2020;9(12):3883. DOI: 10.3390/jcm9123883.
  17. Kim SM, Kim SI, Yu G, Kim JS, Hong SI, Chae B, et al. Role of thromboelastography in the evaluation of septic shock patients with normal prothrombin time and activated partial thromboplastin time. Sci Rep 2021;11:11833.
  18. Luo C, Hu H, Gong J, Zhou Y, Chen Z, Cai S. The value of thromboelastography in the diagnosis of sepsis-induced coagulopathy. Clin Appl Thromb Hemost 2020;26:1076029620951847. DOI: 10.1177/1076029620951847.
  19. Mohapatra P, Kumar A, Singh RK, Gupta R, Hussain M, Singh S, et al. The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using thromboelastometry: A prospective observational study. Indian J Crit Care Med 2023;27(9):625–634.
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