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VOLUME 28 , ISSUE 3 ( March, 2024 ) > List of Articles


To C or not to C? Designing a Pragmatic Trial to Deploy a Novel Immunomodulatory Therapy to Fight Organ Dysfunction in Sepsis

Varun M Angadi, Atul Jindal

Keywords : Immunomodulation, Organ dysfunction, Sepsis, Vitamin C

Citation Information : Angadi VM, Jindal A. To C or not to C? Designing a Pragmatic Trial to Deploy a Novel Immunomodulatory Therapy to Fight Organ Dysfunction in Sepsis. Indian J Crit Care Med 2024; 28 (3):311-311.

DOI: 10.5005/jp-journals-10071-24636

License: CC BY-NC 4.0

Published Online: 29-02-2024

Copyright Statement:  Copyright © 2024; The Author(s).


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  1. Venkataraman R, Sprague S, Ramakrishnan N, Ramachandran P, Jayakumar D, Vijayaraghavan BKT, et al. A pilot feasibility randomized controlled trial of intravenous vitamin C in adults with sepsis in the intensive care unit: The lessening organ dysfunction with vitamin C-India (LOVIT-India) trial. Indian J Crit Care Med 2023;27(12):910–916. DOI: 10.5005/jp-journals-10071-24587.
  2. Toft P, Tønnesen E. Immune-modulating interventions in critically ill septic patients: Pharmacological options. Expert Rev Clin Pharmacol 2011;4(4):491–501. DOI: 10.1586/ecp.11.25.
  3. Fowler AA, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, et al. Effect of vitamin c infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial. JAMA 2019;322(13):1261–1270. DOI: 10.1001/jama.2019.11825.
  4. Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, et al. Intravenous vitamin c in adults with sepsis in the intensive care unit. N Engl J Med 2022;386(25):2387–2398. DOI: 10.1056/NEJMoa2200644.
  5. Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, et al. Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med 2018;378(9):809–818. DOI: 10.1056/NEJMoa1705716.
  6. Collie JTB, Greaves RF, Jones OAH, Eastwood G, Bellomo R. Vitamin C measurement in critical illness: Challenges, methodologies and quality improvements. Clin Chem Lab Med CCLM 2020;58(4):460–470. DOI: 10.1515/cclm-2019-0912.
  7. Rozemeijer S, van der Horst FAL, de Man AME. Measuring vitamin C in critically ill patients: Clinical importance and practical difficulties—Is it time for a surrogate marker? Crit Care 2021;25(1):310. DOI: 10.1186/s13054-021-03670-x.
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