Effect of Admission Day and Time on Patient Outcome: An Observational Study in Intensive Care Units of a Tertiary Care Hospital in India
Mahuya Bhattacharyya
Keywords :
Admission timings, Critically ill patients, Intensive care unit outcome, Length of stay, Mortality, Readmission
Citation Information :
Bhattacharyya M. Effect of Admission Day and Time on Patient Outcome: An Observational Study in Intensive Care Units of a Tertiary Care Hospital in India. Indian J Crit Care Med 2024; 28 (5):436-441.
Background: The current study aimed to assess any association between intensive care unit (ICU) and hospital outcomes with ICU admission timings of critically ill patients.
Methods: Retrospective observational single-center study involving all adult admissions. Each patient admission was categorized in “after-hours” (08:00 p.m.–07:59 a.m.), or “normal-hours” (08:00 a.m.–07:59 p.m.), “Weekday” (Monday–Saturday), or “Weekend” (Sunday), “Same day” (admission directly to ICU) or “other day admission” (admission to ICU after a hospital stay of ≥24 hours). Intensive care unit and hospital mortality, length of stay (LOS), and ICU readmission were assessed for any association with different admission timings.
Results: Among 3,029 patients, 54.2% (1,668) were male, with mean age 66.49 (SD ± 15.69) years, mean acute physiology and chronic health evaluation-IV (APACHE-IV) score 55.5 (SD ± 26.3). Around 86.1% of admission occurred during weekdays, 13.9% on weekends, 57.4% normal-hours, 42.6% after-hours, 66.3% same day and 33.7% other day admission. Intensive care unit and hospital mortality were 10.8 and 14.2% respectively. Neither ICU nor hospital mortality were significantly different among patients admitted normal vs after-hours (p = 0.32, 0.23), and weekdays vs weekends (p = 0.09, 0.93), nor was ICU LOS (p = 0.21, 0.74). Intensive care unit and hospital mortality (p = 0.001), DORB (p = 0.001), hospital LOS (p = 0.001), and readmission to ICU (p = 0.001) were significantly higher in the other day admission group compared to same-day admission. In a multivariate regression analysis age, APACHE IV score along with other day admission to ICU did have a significant effect on both ICU and hospital mortality.
Conclusion: Intensive care unit and hospital mortality and LOS did not differ significantly with hours or days of ICU admission though they were significantly higher in other day admission groups.
Galloway M, Hegarty A, McGill S, Arulkumaran N, Brett SJ, Harrison D. The effect of ICU out-of-hours admission on mortality: A systematic review and meta-analysis. Crit Care Med 2018;46(2):290–299. DOI: 10.1097/CCM.0000000000002837.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345(19):1368–1377. DOI: 10.1056/NEJMoa010307.
Meynaar IA, van der Spoel JI, Rommes JH, van Spreuwel-Verheijen M, Bosman RJ, Spronk PE. Off hour admission to an intensivist-led ICU is not associated with increased mortality. Crit Care 2009;13(3):R84. DOI: 10.1186/cc7904.
Cavallazzi R, Marik PE, Hirani A, Pachinburavan M, Vasu TS, Leiby BE. Association between time of admission to the ICU and mortality: A systematic review and metaanalysis. Chest 2010;138(1):68–75. DOI: 10.1378/chest.09-3018.
Vest-Hansen B, Riis AH, Sørensen HT, Christiansen CF. Out-of-hours and weekend admissions to Danish medical departments: Admission rates and 30-day mortality for 20 common medical conditions. BMJ Open 2015;5(3):e006731. DOI: 10.1136/bmjopen-2014- 006731.
Bhonagiri D, Pilcher DV, Bailey MJ. Increased mortality associated with after-hours and weekend admission to the intensive care unit: A retrospective analysis. Med J Aust 2011;194(6):287–292. DOI: 10.5694/j.1326-5377.2011.tb02976.x.
Zampieri FG, Lisboa TC, Correa TD, Bozza FA, Ferez M, Fernandes HS, et al. Role of organisational factors on the “weekend effect” in critically ill patients in Brazil: A retrospective cohort analysis. BMJ Open 2018;8(1):e018541. DOI: 10.1136/bmjopen-2017-018541.
Arulkumaran N, Harrison DA, Brett SJ. Association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult general critical care units: Cohort study exploring the “weekend effect”. Br J Anaesth 2017;118(1): 112–122. DOI: 10.1093/bja/aew398.
Brunot V, Landreau L, Corne P, Platon L, Besnard N, Buzançais A, et al. Mortality associated with night and weekend admissions to ICU with onsite intensivist coverage: Results of a nine-year Cohort Study (2006–2014). PLoS ONE 2016;11(12):e0168548. DOI: 10.1371/journal.pone.0168548.
Orsini J, Rajayer S, Ahmad N, Din N, Morante J, Malik R, et al. Effects of time and day of admission on the outcome of critically ill patients admitted to ICU. J Community Hosp Intern Med Perspect 2016;6(6):33478. DOI: 10.3402/jchimp.v6.33478.
Namikata Y, Matsuoka Y, Ito J, Seo R, Hijikata Y, Itaya T, et al. Association between ICU admission during off-hours and in-hospital mortality: A multicenter registry in Japan. J Intensive Care 2022;10(1):41. DOI: 10.1186/s40560-022-00634-3.
Escobar GJ, Greene JD, Gardner MN, Marelich GP, Quick B, Kipnis P. Intra-hospital transfers to a higher level of care: Contribution to total hospital and intensive care unit (ICU) mortality and length of stay (LOS). J Hosp Med 2011;6(2):74–80. DOI: 10.1002/jhm.817.
Luyt CE, Combes A, Aegerter P, Guidet B, Trouillet JL, Gibert C, et al. Mortality among patients admitted to intensive care units during weekday day shifts compared with off hours. Crit Care Med 2007;35(1):3–11. DOI: 10.1097/01.CCM.0000249832.36518.11.
Arabi Y, Alshimemeri A, Taher S. Weekend and weeknight admissions have the same outcome of weekday admissions to an intensive care unit with onsite intensivist coverage. Crit Care Med 2006;34(3): 605–611. DOI: 10.1097/01.ccm.0000203947.60552.dd.
Wunsch H, Mapstone J, Brady T, Hanks R, Rowan K. Hospital mortality associated with day and time of admission to intensive care units. Intensive Care Med 2004;30(5):895–901. DOI: 10.1007/s00134-004-2170-3.
Barnett MJ, Kaboli PJ, Sirio CA, Rosenthal GE. Day of the week of intensive care admission and patient outcomes: A multisite regional evaluation. Med Care 2002;40(6):530–539. DOI: 10.1097/00005650-200206000-00010.
Kuijsten HAJM, Brinkman S, Meynaar IA, Spronk PE, van der Spoel JI, Bosman RJ, et al. Hospital mortality is associated with ICU admission time. Intensive Care Med 2010;36(10):1765–1771. DOI: 10.1007/s00134-010-1918-1.
Kevat DA, Davies AR, Cameron PA, Rajaratnam SM. Increased mortality associated with after-hours and weekend admission to the intensivecare unit: A retrospective analysis. Med J Aust 2011;194(11):616. DOI: 10.5694/j.1326-5377.2011.tb03126.x.
Zhou X, Weng J, Xu Z, Yang J, Lin J, Hou R, et al. Effect of admission and discharge times on hospital mortality in patients with sepsis. Crit Care Med 2023;51(3):e81–e89. DOI: 10.1097/CCM.00000000000 05767.
Needleman J, Buerhaus P, Pankratz VS, Leibson CL, Stevens SR, Harris M. Nurse staffing and inpatient hospital mortality. N Engl J Med 2011;364(11):1037–1045. DOI: 10.1056/NEJMsa1001025.
Laupland KB, Shahpori R, Kirkpatrick AW, Stelfox HT. Hospital mortality among adults admitted to and discharged from intensive care on weekends and evenings. J Crit Care 2008;23(3):317–324. DOI: 10.1016/j.jcrc.2007.09.001.
Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, PearseRM, Grocott MPW, et al. Mortality of emergency general surgical patients and associations with hospital structures and processes. Br J Anaesth 2016;116(1):54–62. DOI: 10.1093/bja/aev372.
Carr BG, Reilly PM, Schwab CW, Branas CC, Geiger J, Wiebe DJ. Weekend and night outcomes in a statewide trauma system. Arch Surg 2011;146(7):810–817. DOI: 10.1001/archsurg.2011.60.
Li L, Rothwell P, Oxford Vascular Study. Biases in detection of apparent “weekend effect” on outcome with administrative coding data: Population based study of stroke. Br Med J 2016;353:i2648. DOI: 10.1136/bmj.i2648.