Comparative Evaluation of Mortality Predictors in Trauma Patients: A Prospective Single-center Observational Study Assessing Injury Severity Score Revised Trauma Score Trauma and Injury Severity Score and Acute Physiology and Chronic Health Evaluation II Scores
Citation Information :
Gupta J, Kshirsagar S, Naik S, Pande A. Comparative Evaluation of Mortality Predictors in Trauma Patients: A Prospective Single-center Observational Study Assessing Injury Severity Score Revised Trauma Score Trauma and Injury Severity Score and Acute Physiology and Chronic Health Evaluation II Scores. Indian J Crit Care Med 2024; 28 (5):475-482.
Aim: This prospective cohort study aimed to compare the predictive accuracy of outcome (survival/death) among trauma patients using various prognostic scores.
Methods: Over 3 months, 240 trauma patients in a tertiary care hospital were assessed for demographic details, trauma characteristics, vital signs, Glasgow coma scale, arterial blood gas values, and lab markers. Injury severity score (ISS), revised trauma score (RTS), trauma and injury severity score (TRISS), and acute physiology and chronic health evaluation II (APACHE II) were applied at admission, 24 hours, and 48 hours post-admission.
Results: Road traffic accidents (55.83%) were the primary cause of trauma, followed by falls (33.75%) and violence (10.41%). The all-cause mortality rate was 23.33%, with 34.16% requiring ICU admission. Head injuries (65.83%) were both the most frequent injury site and cause of mortality.
Conclusion: Analysis indicated that APACHE II outperformed other scores in predicting outcomes, with ISS following closely. The study concludes that trauma severity correlates with ICU admission and mortality, emphasizing APACHE II as a superior predictor, particularly for traumatic brain injuries leading to ICU admission and mortality.
Clinical significance: This study contributes to the existing body of knowledge by addressing the gap in comparing prognostic abilities among scoring systems for trauma patients. The unexpected superiority of APACHE II suggests its potential as a valuable tool in predicting outcomes in this specific patient population.
Esme H, Solak O, Yurumez Y, Yavuz Y, Terzi Y, Sezer M, et al. The prognostic importance of trauma scoring systems for blunt thoracic trauma. Thorac Cardiovasc Surg 2007;55(3):190–195. DOI: https://doi.org/10.1055/s-2006-955883.
Lefering R. Trauma score systems for quality assessment. Eur J Trauma 2002;28:52–63. DOI: https://doi.org/10.1007/s00068-002-0170-y.
Himmelseher S, Pfenninger E, Strohmenger H. Brauchen [Do we need trauma scoring in emergency medicine?]. Anaesthesist 1994;43(6):376–384. DOI: https://doi.org/10.1007/s001010050070.
Papadimitriou-Olivgeris M, Panteli E, Koutsileou K, Boulovana M, Zotou A, Marangos M, et al. Predictors of mortality of trauma patients admitted to the ICU: A retrospective observational study. Braz J Anesthesiol 2021;71(1):23–30. DOI: https://doi.org/10.1016/j.bjane.2020.12.006.
Nahm FS. Receiver operating characteristic curve: Overview and practical use for clinicians. Korean J Anesthesiol 2022;75(1):25–36. DOI: https://doi.org/10.4097/kja.21209.
Amato S, Bonnell L, Mohan M, Roy N, Malhotra A. Comparing trauma mortality of injured patients in India and the USA: A risk-adjusted analysis. Trauma Surg Acute Care Open 2021;6(1):e000719. DOI: https://doi.org/10.1136/tsaco-2021-000719.
Roy N, Kizhakke Veetil D, Khajanchi MU, Kumar V, Solomon H, Kamble J, et al. Learning from 2523 trauma deaths in India opportunities to prevent in-hospital deaths. BMC Health Serv Res 2017;17(1):142. DOI: https://doi.org/10.1186/s12913-017-2085-7.
Deng Q, Tang B, Xue C, Liu Y, Liu X, Yipeng Lv, et al. Comparison of the ability to predict mortality between the injury severity score and the new injury severity score: A meta-analysis. Int J Environ Res Public Health 2016;13(8):825. DOI: https://doi.org/10.3390/ijerph13080825.
Kim SC, Kim DH, Kim TY, Kang C, Lee HS, Jeong JH, et al. The revised trauma score plus serum albumin level improves the prediction of mortality in trauma patients. Am J Emerg Med 2017;35(12):1882–1886. https://doi.org/10.1016/j.ajem.2017.06.027.
de Alencar Domingues C, de Sousa RMC, de Souza Nogueira L, Poggetti RS, Fontes B, Muñoz. The role of the new trauma and injury severity score (NTRISS) for survival prediction. Rev Esc Enferm USP 2011;45(6):1353–1358. DOI: https://doi.org/10.1590/S0080-62342011000600011.
Huang J, Xuan D, Li X, Li M, Yuanling Z, Hejian Z, et al. The value of APACHE II in predicting mortality after paraquat poisoning in Chinese and Korean population: A systematic review and meta-analysis. Medicine (Baltimore) 2017;96(30):e6838. DOI: https://doi.org/10.1097/MD.0000000000006838.
Singh J, Gupta G, Garg R, Ashish G. Evaluation of trauma and prediction of outcome using TRISS method. J Emerg Trauma Shock 2011;4(4):446–449. DOI: https://doi.org/10.4103/0974-2700.86626.
Merchant AAH, Shaukat N, Ashraf N, Hassan S, Jarrar Z, Abbasi A, et al. Which curve is better? A comparative analysis of trauma scoring systems in a South Asian country. Trauma Surg Acute Care Open 2023;8(1):e001171. DOI: https://doi.org/10.1136/tsaco-2023-001171.
Hofman K, Primack A, Keusch G, Hrynkow S. Addressing the growing burden of trauma and injury in low- and middle-income countries. Am J Public Health 2005;95(1):13–17. DOI: https://doi.org/10.2105/AJPH.2004.039354.
Basak D, Chatterjee S, Attergrim J, Sharma MR, Soni KD, Verma S, et al. Glasgow Coma Scale compared to other trauma scores in discriminating in-hospital mortality of traumatic brain injury patients admitted to urban Indian hospitals: A multicentre prospective cohort study. Injury 2023;54(1):93–99. DOI: https://doi.org/10.1016/j.injury.2022.09.035.
Mohammed Z, Saleh Y, AbdelSalam EM, El-Bana E, Hirshon JM. Evaluation of the revised trauma score, MGAP, and GAP scoring systems in predicting mortality of adult trauma patients in a low-resource setting. BMC Emerg Med 2022;22(1):90. DOI: https://doi.org/10.1186/s12873-022-00653-1.
Yue-feng MA, Lei S, Jun GU, Mao A, Guan-Yu J. Analysis of clinical risk factors associated with mortality of severely injured multiple trauma patients with acute lung injury. Chin Med J 2009;122(6):701–705. DOI: https://doi.org/10.3760/cma.j.issn.0366-6999.2009.06.021.
Hefny AF, Idris K, Eid HO, Abu-Zidan FM. Factors affecting mortality of critical care trauma patients. Afr Health Sci 2013;13(3):731–735. DOI: https://doi.org/10.4314/ahs.v13i3.30.
Haagsma JA, Graetz N, Bolliger I, Naghavi M, Higashi H, Mullany EC, et al. The global burden of injury: Incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013. Inj Prev 2016;22(1):3–18. DOI: https://doi.org/10.1136/injuryprev-2015-041616.
Mengistu Z, Azaj A. Trauma severities scores and their prediction of outcome among trauma patients in two hospitals of Addis Ababa, Ethiopia. Ethiop Med J 2012;50(3):231–237. DOI: https://pubmed.ncbi.nlm.nih.gov/23409406/.
Gururaj G. Injuries in India: A national perspective. NMCH Background Papers: Burden of disease in India. 325–347. Available from: https://nimhans.ac.in/wp-content/uploads/2019/02/BD_7-India-Injury-Report_0.pdf.
Moore L, André L, Natalie L, Belkacem A, Eric B, Moishe L, et al. Statistical validation of the revised trauma score. J Trauma 2006;60(2):305–311. DOI: https://doi.org/10.1097/01.ta.0000200840.89685.b0.
Pfeifer R, Tarkin IS, Rocos B, Pape HC. Patterns of mortality and causes of death in polytrauma patients has anything changed? Injury 2009;40(9):907–911. DOI: https://doi.org/10.1016/j.injury.2009.05.006.
Ulvik A, Wentzel-Larsen T, Flaatten H. Trauma patients in the intensive care unit: Short- and long-term survival and predictors of 30-day mortality. Acta Anaesthesiol Scand 2007;51(2):171–177. DOI: https://doi.org/10.1111/j.1399-6576.2006.01207.x.
Feldhaus I, Carvalho M, Waiz G, Igu J, Matthay Z, Dicker R, et al. The feasibility, appropriateness, and applicability of trauma scoring systems in low and middle-income countries: A systematic review. Trauma Surg Acute Care Open 2020;5(1):e000424. DOI: https://doi.org/10.1136/tsaco-2019-000424.
Hwang SY, Lee JH, Lee YH, Hong CK, Sung AJ, Choi YC. Comparison of the sequential organ failure assessment, acute physiology and chronic health evaluation II scoring system, and trauma and injury severity score method for predicting the outcomes of intensive care unit trauma patients. Am J Emerg Med 2012;30(5):749–753. DOI: https://doi.org/10.1016/j.ajem.2011.05.022.
Cho DY, Wang YC. Comparison of the APACHE III, APACHE II and Glasgow Coma Scale in acute head injury for prediction of mortality and functional outcome. Intensive Care Med 1997;23(1):77–84. DOI: https://doi.org/10.1007/s001340050294.
McAnena OJ, Moore FA, Moore EE, Kenneth ML, Marx JA, Pepe P, et al. Invalidation of the APACHE II scoring system for patients with acute trauma. J Trauma 1992;33(4):504–506. discussion 506–507. DOI: https://doi.org/10.1097/00005373-199210000-00003.
Tamim H, Al Hazzouri AZ, Mahfoud Z, Atoui M, El-Chemaly S. The injury severity score or the new injury severity score for predicting mortality, intensive care unit admission and length of hospital stay: Experience from a university hospital in a developing country. Injury 2008;39(1):115–120. DOI: https://doi.org/10.1016/j.injury.2007. 06.007.
Laytin AD, Kumar V, Juillard CJ, Sarang B, Lashoher A, Roy N, et al. Choice of injury scoring system in low- and middle-income countries: Lessons from Mumbai. Injury 2015;46(12):2491–2497. DOI: https://doi.org/10.1016/j.injury.2015.06.029.
Hung YW, He H, Mehmood A, Botchey I, Saidi H, Hyder AA, et al. Exploring injury severity measures and in-hospital mortality: A multi-hospital study in Kenya. Injury 2017;48(10):2112–2118. DOI: https://doi.org/10.1016/j.injury.2017.07.001.
Eisenberg RL. TRISS methodology in penetrating trauma: 198 patients at Baragwanath Hospital. Aust N Z J Surg 1993;63(7):515–519. DOI: https://doi.org/10.1111/j.1445-2197.1993.tb00443.x.
Weeks SR, Juillard CJ, Monono ME, Etoundi GA, Ngamby MK, Hyder AA, et al. Is the Kampala trauma score an effective predictor of mortality in low-resource settings? A comparison of multiple trauma severity scores. World J Surg 2014;38(8):1905–1911. DOI: https://doi.org/10.1007/s00268-014-2496-0.
Moini M, Rezaishiraz H, Zafarghandi MR. Characteristics and outcome of injured patients treated in urban trauma centers in Iran. J Trauma 2000;48(3):503–507. DOI: https://doi.org/10.1097/00005373-200003000-00023.
MacLeod JBA, Kobusingye O, Frost C, Lett R, Kirya F, Shulman C. A comparison of the kampala trauma score (KTS) with the revised trauma score (RTS), injury severity score (ISS) and the TRISS method in a Ugandan trauma registry. Eur J Trauma 2003;2:392–398. DOI: https://doi.org/10.1007/s00068-003-1277-5.