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VOLUME 28 , ISSUE 6 ( June, 2024 ) > List of Articles

PROTOCOL

Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multicentric Cohort Study

Sumalatha Arunachala, Sindhuja Devapal, Dayana Shre N Swamy, Mandya V Greeshma, Imaad Ul Hussain, Jayaraj B Siddaiah, Devasahayam J Christopher, Sowmya Malamardi, Mohammed Kaleem Ullah, Mohammed Saeed, Ashwaghosha Parthasarathi, J Jeevan, Jeevan Kumar, N Harsha, Laxmegowda, Chetak K Basavaraj, Pongali B Raghavendra, Komarla S Lokesh, L Nischal Raj, DK Suneetha, MM Basavaraju, R Madhu Kumar, H Basavanagowdappa, MN Suma, Prashanth M Vishwanath, Suresh Babu, P Ashok, Tandure Varsha, Shreya Chandran, Hariharan Venkataraman, Dinesh HN, Skanda Swaroop, Koustav Ganguly, Swapna Upadhyay, Padukudru A Mahesh

Keywords : Acute exacerbation, Intensive care unit, Malnutrition, Morbidity, Obesity, Phenotypes, Severe and very severe COPD, Survival

Citation Information : Arunachala S, Devapal S, Swamy DS, Greeshma MV, Ul Hussain I, Siddaiah JB, Christopher DJ, Malamardi S, Ullah MK, Saeed M, Parthasarathi A, Jeevan J, Kumar J, Harsha N, Laxmegowda, Basavaraj CK, Raghavendra PB, Lokesh KS, Raj LN, Suneetha D, Basavaraju M, Kumar RM, Basavanagowdappa H, Suma M, Vishwanath PM, Babu S, Ashok P, Varsha T, Chandran S, Venkataraman H, HN D, Swaroop S, Ganguly K, Upadhyay S, Mahesh PA. Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multicentric Cohort Study. Indian J Crit Care Med 2024; 28 (6):552-560.

DOI: 10.5005/jp-journals-10071-24728

License: CC BY-NC 4.0

Published Online: 31-05-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. However, there is a lack of comprehensive data from low- and middle-income countries (LMICs) regarding factors influencing COPD outcomes, particularly in regions where biomass exposure is prevalent. Objective: The Factors Affecting Survival in Severe and Very Severe COPD Patients Admitted to Tertiary Centers of India (FAST) study aims to address this gap by evaluating factors impacting survival and exacerbation rates among COPD patients in LMICs like India, with a specific focus on biomass exposure, clinical phenotypes, and nutritional status in patients admitted to the Intensive Care Unit (ICU). Methods: The FAST study is an observational cohort study conducted in university teaching hospitals across India. The study aims to enroll 1000 COPD patients admitted to the ICU meeting specific inclusion criteria, with follow-up assessments conducted every 6 months over a 2-year period. Data collection includes demographic information, clinical manifestations, laboratory investigations, pulmonary function tests, medications, nutritional status, mental health, and health-related quality of life. Adjudication of exacerbations and mortality will also be undertaken. The FAST study seeks to provide crucial insights into COPD outcomes in LMICs, informing more precise management strategies and mitigating the burden of COPD in these settings. By evaluating factors such as biomass exposure, clinical phenotypes, and nutritional status, the study aims to address key knowledge gaps in COPD research.

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  1. Chronic Obstructive Pulmonary Disease (COPD). Available online: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd) (Accessed on 02 January 2023).
  2. Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: A systematic review and modelling analysis. Lancet Respir Med 2022;10(5):447–458. DOI: 10.1016/S2213-2600(21)00511-7.
  3. Quaderi SA, Hurst JR. The unmet global burden of COPD. Glob Health Epidemiol Genom 2018;3:e4. DOI: 10.1017/gheg.2018.1.
  4. Institute for Health Metrics and Evaluation (IHME). GBD Compare. Seattle, WA: IHME, University of Washington, 2015. Available from: http://Vizhub.Healthdata.Org/Gbd-Compare. (Accessed on 02 January 2023) Available online: http://vizhub.healthdata.org/gbd-compare.
  5. Foo J, Landis SH, Maskell J, Oh Y-M, van der Molen T, Han MK, et al. Continuing to confront COPD International Patient Survey: Economic impact of COPD in 12 countries. PLoS ONE 2016;11(4):e0152618. DOI: 10.1371/journal.pone.0152618.
  6. Iheanacho I, Zhang S, King D, Rizzo M, Ismaila AS. Economic burden of chronic obstructive pulmonary disease (COPD): A systematic literature review. Int J Chron Obstruct Pulmon Dis 2020;15:439–460. DOI: 10.2147/COPD.S234942.
  7. Global Health Estimates: Life Expectancy and Leading Causes of Death and Disability. Available online: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates. (Accessed on 17 November 2021).
  8. India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: The Global Burden of Disease Study 1990–2016. Lancet Glob Health 2018;6(12):e1363–e1374. DOI: 10.1016/S2214-109X(18)30409-1.
  9. Lakiang T, Nair NS, Ramaswamy A, Singhal U. Economic impact of chronic obstructive pulmonary disease: A cross-sectional study at teaching hospital in South India. J Family Med Prim Care 2018;7(5):1002–1006. DOI: 10.4103/jfmpc.jfmpc_75_16.
  10. Assad NA, Kapoor V, Sood A. Biomass smoke exposure and chronic lung disease. Curr Opin Pulm Med 2016;22(2):150–157. DOI: 10.1097/MCP.0000000000000246.
  11. Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1(6077):1645–1648. DOI: 10.1136/bmj.1.6077.1645.
  12. Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: The GOLD science committee report 2019. Eur Respir J 2019;53(5):1900164. DOI: 10.1183/13993003.00164-2019.
  13. Friedlander AL, Lynch D, Dyar LA, Bowler RP. Phenotypes of chronic obstructive pulmonary disease. COPD 2007;4(4):355–384. DOI: 10.1080/15412550701629663.
  14. Miravitlles M, Soler-Cataluña JJ, Calle M, Soriano JB. Treatment of COPD by clinical phenotypes: Putting old evidence into clinical practice. Eur Respir J 2013;41(6):1252–1256. DOI: 10.1183/09031936.0011 8912.
  15. Kaleem Ullah M, Parthasarathi A, Biligere Siddaiah J, Vishwanath P, Upadhyay S, Ganguly K, et al. Impact of acute exacerbation and its phenotypes on the clinical outcomes of chronic obstructive pulmonary disease in hospitalized patients: A cross-sectional study. Toxics 2022;10(11):667. DOI: 10.3390/toxics10110667.
  16. Mirza S, Benzo R. Chronic obstructive pulmonary disease phenotypes: Implications for care. Mayo Clin Proc 2017;92(7):1104–1112. DOI: 10.1016/j.mayocp.2017.03.020.
  17. Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363(12):1128–1138. DOI: 10.1056/NEJMoa0909883.
  18. Halpin DM, Decramer M, Celli B, Kesten S, Liu D, Tashkin DP. Exacerbation frequency and course of COPD. Int J Chron Obstruct Pulmon Dis 2012;7:653–661. DOI: 10.2147/COPD.S34186.
  19. Pinto LM, Alghamdi M, Benedetti A, Zaihra T, Landry T, Bourbeau J. Derivation and validation of clinical phenotypes for COPD: A systematic review. Respir Res 2015;16(1):50. DOI: 10.1186/s12931-015-0208-4.
  20. Kuźnar-Kamińska B, Batura-Gabryel H, Brajer B, Kamiński J. Analysis of nutritional status disorders in patients with chronic obstructive pulmonary disease. Pneumonol Alergol Pol 2008;76(5):327–333. PMID: 19003762.
  21. Casanova Macario C, de Torres Tajes JP, Palmero MA. COPD disease and malnutrition. Arch Bronconeumol 2009;45(Suppl 4):31–35. DOI: 10.1016/S0300-2896(09)72861-3.
  22. Itoh M, Tsuji T, Nemoto K, Nakamura H, Aoshiba K. Undernutrition in patients with COPD and its treatment. Nutrients 2013;5(4):1316–1335. DOI: 10.3390/nu5041316.
  23. Schols AM. Nutrition in chronic obstructive pulmonary disease. Curr Opin Pulm Med 2000;6(2):110–115. DOI: 10.1097/00063198-200003000-00005.
  24. Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157(6 Pt 1):1791–1797. DOI: 10.1164/ajrccm.157.6.9705017.
  25. Vermeeren MA, Creutzberg EC, Schols AM, Postma DS, Pieters WR, Roldaan AC, et al. Prevalence of nutritional depletion in a large out-patient population of patients with COPD. Respir Med 2006;100(8):1349–1355. DOI: 10.1016/j.rmed.2005.11.023.
  26. Girón R, Matesanz C, García-Río F, de Santiago E, Mancha A, Rodríguez-Salvanés F, et al. Nutritional state during COPD exacerbation: clinical and prognostic implications. Ann Nutr Metab 2009;54(1):52–58. DOI: 10.1159/000205960.
  27. Grönberg AM, Slinde F, Engström CP, Hulthén L, Larsson S. Dietary problems in patients with severe chronic obstructive pulmonary disease. J Hum Nutr Diet 2005;18(6):445–452. DOI: 10.1111/j.1365-277X.2005.00649.x.
  28. Arterburn DE, McDonell MB, Hedrick SC, Diehr P, Fihn SD. Association of body weight with condition-specific quality of life in male veterans. Am J Med 2004;117(10):738–746. DOI: 10.1016/j.amjmed.2004. 06.031.
  29. Cecere LM, Littman AJ, Slatore CG, Udris EM, Bryson CL, Boyko EJ, et al. Obesity and COPD: Associated symptoms, health-related quality of life, and medication use. COPD 2011;8(4):275–284. DOI: 10.3109/15412555.2011.586660.
  30. Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;160(6):1856–1861. DOI: 10.1164/ajrccm.160.6.9902115.
  31. Zewari S, Vos P, van den Elshout F, Dekhuijzen R, Heijdra Y. Obesity in COPD: Revealed and unrevealed issues. COPD 2017;14(6):663–673. DOI: 10.1080/15412555.2017.1383978.
  32. Gudmundsson G, Ulrik CS, Gislason T, Lindberg E, Brøndum E, Bakke P, et al. Long-term survival in patients hospitalized for chronic obstructive pulmonary disease: A prospective observational study in the Nordic countries. Int J Chron Obstruct Pulmon Dis 2012;7:571–576. DOI: 10.2147/COPD.S34466.
  33. Celli BR, Cote CG, Lareau SC, Meek PM. Predictors of survival in COPD: More than just the FEV1. Respir Med 2008;102(Suppl 1):S27–S35. DOI: 10.1016/S0954-6111(08)70005-2.
  34. Ställberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, et al. Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients. NPJ Prim Care Respir Med 2018;28(1):33. DOI: 10.1038/s41533-018-0101-y.
  35. Miniati M, Monti S, Pavlickova I, Bottai M. Survival in COPD: Impact of lung dysfunction and comorbidities. Medicine (Baltimore) 2014;93(12):e76. DOI: 10.1097/MD.0000000000000076.
  36. Abukhalaf J, Davidson R, Villalobos N, Meek P, Petersen H, Sood A, et al. Chronic obstructive pulmonary disease mortality, a competing risk analysis. Clin Respir J 2018;12(11):2598–2605. DOI: 10.1111/crj.12963.
  37. Eroglu SA, Gunen H, Yakar HI, Yildiz E, Kavas M, Duman D. Influence of comorbidities in long-term survival of chronic obstructive pulmonary disease patients. J Thorac Dis 2019;11(4):1379–1386. DOI: 10.21037/jtd.2019.03.78.
  38. Hersh CP, DeMeo DL, Al-Ansari E, Carey VJ, Reilly JJ, Ginns LC, et al. Predictors of survival in severe, early onset COPD. Chest 2004;126(5):1443–1451. DOI: 10.1378/chest.126.5.1443.
  39. Gunen H, Hacievliyagil SS, Kosar F, Mutlu LC, Gulbas G, Pehlivan E, et al. Factors affecting survival of hospitalised patients with COPD. Eur Respir J 2005;26(2):234–241. DOI: 10.1183/09031936.05.000 24804.
  40. Berry CE, Wise RA. Mortality in COPD: Causes, risk factors, and prevention. COPD 2010;7(5):375–382. DOI: 10.3109/15412555.2010. 510160.
  41. Law S, Boyd S, MacDonald J, Raeside D, Anderson D. Predictors of survival in patients with chronic obstructive pulmonary disease receiving long-term oxygen therapy. BMJ Support Palliat Care 2014;4(2):140–145. DOI: 10.1136/bmjspcare-2012-000432.
  42. Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, et al. Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 2014;69(5):491–494. DOI: 10.1136/thoraxjnl-2013-203897.
  43. Doiron D, de Hoogh K, Probst-Hensch N, Fortier I, Cai Y, De Matteis S, et al. Air pollution, lung function and COPD: Results from the population-based UK Biobank study. Eur Respir J 2019;54(1):1802140. DOI: 10.1183/13993003.02140-2018.
  44. Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, et al. Clinical epidemiology of COPD: Insights from 10 years of the COPDGene study. Chest 2019;156(2):228–238. DOI: 10.1016/j.chest.2019.04.135.
  45. Pompe E, Strand M, van Rikxoort EM, Hoffman EA, Barr RG, Charbonnier JP, et al. Five-year progression of emphysema and air trapping at CT in smokers with and those without chronic obstructive pulmonary disease: Results from the COPDGene Study. Radiology 2020;295(1):218–226. DOI: 10.1148/radiol.20201 91429.
  46. Vestbo J, Anderson W, Coxson HO, Crim C, Dawber F, Edwards L, et al. Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE). Eur Respir J 2008;31(4):869–873. DOI: 10.1183/09031936.00111707.
  47. Torres-Duque CA, García-Rodriguez MC, González-García M. Is chronic obstructive pulmonary disease caused by wood smoke a different phenotype or a different entity? Arch Bronconeumol 2016;52(8):425–431. DOI: 10.1016/j.arbres.2016.04.004.
  48. Sana A, Somda SMA, Meda N, Bouland C. Chronic obstructive pulmonary disease associated with biomass fuel use in women: A systematic review and meta-analysis. BMJ Open Respir Res 2018;5(1):e000246. DOI: 10.1136/bmjresp-2017-000246.
  49. Dicker AJ, Huang JTJ, Lonergan M, Keir HR, Fong CJ, Tan B, et al. The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease. J Allergy Clin Immunol 2021;147(1):158–167. DOI: 10.1016/j.jaci.2020.02.040.
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