Aims and background: Emergency nurses are working in a stress-prone environment. It is critical to ensure adequate psychological aids to cope with the distress at work. The objective of this systematic review was to explore and evaluate the studies that have discussed the role of mindfulness-based interventions on occupational distress and resilience among emergency nursing professionals. Materials and methods: This study was a systematic review. The databases used for this review were PubMed and Scopus from 2018 to 2023. Interventional studies published in English that used mindfulness-based techniques among emergency and critical care nurses to alleviate their occupational distress and burnout and improve resilience were considered for review. This systematic review adheres to the PRISMA guidelines. The study was registered with PROSPERO (CRD42024512071). Results: Ten studies were found to be eligible and included in this review. Out of the 10 studies included, nine studies demonstrated the improvement of psychological well-being, compassion, and resilience followed by the intervention. Conclusion: The findings of this systematic review suggest that mindfulness-centered interventions can be an effective strategy to cope with distress and burnout and in building compassion and resilience among the healthcare professionals who are employed at the emergency and critical care department in a hospital. Clinical significance: Incorporating mindfulness-based practices and interventions in healthcare settings, especially among critical care and emergency departments may help in ameliorating the professional well-being of the staff which may result in a resilient work environment and improvement in the quality of patient care.