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VOLUME 29 , ISSUE 2 ( February, 2025 ) > List of Articles

LETTER TO THE EDITOR

Appropriately Designed Studies are Needed before Thiamine and Vitamin C Plus Hydrocortisone are Judged Non-beneficial in Septic Shock

Josef Finsterer, Carla A Scorza, Fulvio A Scorza

Keywords : Mortality, Sepsis, Shock, Thiamine, Vitamin C

Citation Information : Finsterer J, Scorza CA, Scorza FA. Appropriately Designed Studies are Needed before Thiamine and Vitamin C Plus Hydrocortisone are Judged Non-beneficial in Septic Shock. Indian J Crit Care Med 2025; 29 (2):191-192.

DOI: 10.5005/jp-journals-10071-24889

License: CC BY-NC 4.0

Published Online: 31-01-2025

Copyright Statement:  Copyright © 2025; The Author(s).


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  1. Sharma S, Paneru HR, Shrestha GS, Shrestha PS, Acharya SP. Evaluation of the effects of a combination of vitamin C, thiamine and hydrocortisone vs hydrocortisone alone on ICU outcome in patients with septic shock: A randomized controlled trial. Indian J Crit Care Med 2024;28(11):1147–1152. DOI: 10.5005/jp-journals-10071-24852.
  2. Alissa A, Alrashed MA, Alshaya AI, Al Sulaiman K, Alharbi S. Reevaluating vitamin C in sepsis and septic shock: A potential benefit in severe cases? Front Med (Lausanne) 2024;11:1476242. DOI: 10.3389/fmed.2024.1476242.
  3. Fowler AA 3rd. Vitamin C: Rationale for its use in sepsis-induced acute respiratory distress syndrome (ARDS). Antioxidants (Basel) 2024;13(1):95. DOI: 10.3390/antiox13010095.
  4. van der Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect Dis 2008;8(1):32–43. DOI: 10.1016/S1473-3099(07)70265-7.
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