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VOLUME 9 , ISSUE 1 ( January, 2005 ) > List of Articles


Hypersensitivity and dose related side effects of phenytoin mimicking critical illness

Lalitha V. Pillai, Dhananjay P. Ambike, Satish Pataskar, S. M. K. Hussainy, Sunil Vishwasrao, Maruti M. Gaikwad

Keywords : Phenytoin, skin lesion, allergic alveolitis, dyskinesia, Phenytoin hypersensitivity syndrome (PHS)

Citation Information : Pillai LV, Ambike DP, Pataskar S, Hussainy SM, Vishwasrao S, Gaikwad MM. Hypersensitivity and dose related side effects of phenytoin mimicking critical illness. Indian J Crit Care Med 2005; 9 (1):22-27.

DOI: 10.4103/0972-5229.16265

License: CC BY-ND 3.0

Published Online: 01-09-2009

Copyright Statement:  Copyright © 2005; The Author(s).


OBJECTIVE: To describe phenytoin-induced rare hypersensitivity and dose related reactions, emphasizing the importance of early omission of drug to achieve clinical improvement. DESIGN: Case series and review of literature. SETTING: Tertiary level medical intensive care unit. PATIENTS: Three cases, two of whom had hypersensitivity reactions and the third had drug-induced dyskinesia. INTERVENTION: Omission of phenytoin and corticosteroid therapy in two cases. RESULTS: Improvement and discharge. CONCLUSION: A high index of suspicion of drug-induced complications is necessary especially when multiple drugs are being administered to critically ill patients.

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