A 19-year-old male presented with history of massive hemoptysis. The patient was kept on mechanical ventilation because of severe hypoxia. Lung protective ventilation with low tidal volume was given in view of very poor pulmonary compliance. During the course of treatment, the patient developed a very high CO 2 level of 373 mmHg. The patient was successfully weaned off on the 9 th day without any obvious adverse consequences.
Hickling KG, Walsh J, Hendersons S, Jackson R. Low mortality rate in adult respiratory distress syndrome using low-volume, pressure limited ventilation with permissive hypercapnia: A prospective study. Crit Care Med 1994;22:1568-78.
Ijland MM, Heunks LM, Hoeven JG. Bench-to bedside review: Hypercapnic acidosis in lung injury- From ′permissive′ to ′therapeutic′. Crit Care 2010;14:237.
Ohmura A, Sha M, Katagiri J. How far can we go with permissive hypercapnia? A case presentation and some biased comments with emphasis on maintaining normal haemoglobin level. Acta Anaesthesiol Scand 1995;107:209-13.
Chonghaile MN, Higgins B, Laffey JG. Permissive hypercapnia: Role in protective lung ventilation strategies. Curr Opin Crit Care 2005;11:56-62.
Thorens JB, Jolliet P, Ritz M, Chevrolet JC. Effects of rapid permissive hypercapnia on hemodynamics, gas exchange, and oxygen transport and consumption during mechanical ventilation for the acute respiratory distress syndrome. Intensive Care Med 1996;22:182-91.
Feihl F, Perret C. Permissive hypercapnia. How permissive should we be? Am J Respir Crit Care Med 1994;150:1722-37.
Potkin RT, Swenson ER. Resuscitation from severe acute hypercapnia. Determinants of tolerance and survival. Chest 1992;102:1742-5.
Mazzeo AT, Spada A, Praticò C, Lucanto T, Santamaria LB. Hypercapnia: What is the limit in paediatric patients? A case of near-fatal asthma successfully treated by multipharmacological approach. Paediatr Anaesth 2004;14:596-603.
Urwin L, Murphy R, Robertson C, Pollok A. A case of extreme hypercapnia: Implications for the prehospital and accident and emergency department management of acutely dyspnoeic patients. Emerg Med J 2004;21:119-20.