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VOLUME 21 , ISSUE 9 ( 2017 ) > List of Articles

RESEARCH ARTICLE

Epidemiology of adult-population sepsis in India: A single center 5 year experience

Sharmila Chatterjee, Mahuya Bhattacharya

Keywords : Epidemiology, intensive care patients, mortality, prevalence, severe sepsis

Citation Information : Chatterjee S, Bhattacharya M. Epidemiology of adult-population sepsis in India: A single center 5 year experience. Indian J Crit Care Med 2017; 21 (9):573-577.

DOI: 10.4103/ijccm.IJCCM_240_17

License: CC BY-ND 3.0

Published Online: 01-12-2015

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Background and Aims: Sepsis is a major worldwide cause of morbidity and mortality. Most sepsis epidemiologic data are from the Western literature. Sparse data from India describe the epidemiology of infection rather than sepsis which is a host response to infection. This study describes the epidemiology of sepsis in the Intensive Care Unit (ICU) of an Indian tertiary care hospital. Subjects and Methods: A prospective study conducted between June 2006 and May 2011. All consecutively admitted patients during the 5 year study >=18 years of age were included and data obtained from hospital in-patient records. Variables measured were the incidence of severe sepsis, ICU, hospital, and 28-day mortality, the median length of ICU stay, median Acute Physiology and Chronic Health Evaluation II (APACHE II) score, infection site, and microbial profile. Results: There were 4711 admissions during the study with 282 (6.2%, 95% confidence interval 2.3, 13.1) admissions with severe sepsis. ICU mortality, hospital mortality, and 28-day mortality were 56%, 63.6%, and 62.8%, respectively. Predominant infection site was respiratory tract. The most common organisms were Gram-negative microbes. The most common microbe was Acinetobacter baumanni. Median APACHE II score on admission was 22 (interquartile range 16–28) and median length of ICU stay was 8 days. Severe sepsis attributable mortality was 85%. Conclusion: Severe sepsis is common in Indian ICUs and is mainly due to Gram-negative organisms. ICU mortality is high in this group and care is resource intensive due to increased length of stay.

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