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VOLUME 22 , ISSUE 6 ( 2018 ) > List of Articles

RESEARCH ARTICLE

Levels and diagnostic value of model-based insulin sensitivity in sepsis: A preliminary study

Wan Fadzlina Wan Muhd Shukeri, Mohd Basri Mat-Nor, Ummu Kulthum Jamaludin, Fatanah Suhaimi, Normy Norafiza Abd Razak, Azrina Md Ralib

Keywords : Critical care, diagnosis, insulin sensitivity, model-based, sepsis

Citation Information : Shukeri WF, Mat-Nor MB, Jamaludin UK, Suhaimi F, Razak NN, Ralib AM. Levels and diagnostic value of model-based insulin sensitivity in sepsis: A preliminary study. Indian J Crit Care Med 2018; 22 (6):402-407.

DOI: 10.4103/ijccm.IJCCM_92_18

License: CC BY-ND 3.0

Published Online: 00-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background and Aims: Currently, there is a lack of real-time metric with high sensitivity and specificity to diagnose sepsis. Insulin sensitivity (SI) may be determined in real-time using mathematical glucose-insulin models; however, its effectiveness as a diagnostic test of sepsis is unknown. Our aims were to determine the levels and diagnostic value of model-based SI for identification of sepsis in critically ill patients. Materials and Methods: In this retrospective, cohort study, we analyzed SI levels in septic (n = 18) and nonseptic (n = 20) patients at 1 (baseline), 4, 8, 12, 16, 20, and 24 h of their Intensive Care Unit admission. Patients with diabetes mellitus Type I or Type II were excluded from the study. The SI levels were derived by fitting the blood glucose levels, insulin infusion and glucose input rates into the Intensive Control of Insulin-Nutrition-Glucose model. Results: The median SI levels were significantly lower in the sepsis than in the nonsepsis at all follow-up time points. The areas under the receiver operating characteristic curve of the model-based SI at baseline for discriminating sepsis from nonsepsis was 0.814 (95% confidence interval, 0.675–0.953). The optimal cutoff point of the SI test was 1.573 × 10−4 L/mu/min. At this cutoff point, the sensitivity was 77.8%, specificity was 75%, positive predictive value was 73.7%, and negative predictive value was 78.9%. Conclusions: Model-based SI ruled in and ruled out sepsis with fairly high sensitivity and specificity in our critically ill nondiabetic patients. These findings can be used as a foundation for further, prospective investigation in this area.


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