Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 22 , ISSUE 10 ( 2018 ) > List of Articles

CASE REPORT

Anti-voltage-gated potassium channel antibody syndrome: A rare cause of hyponatremia in intensive care unit

Shashi Prakash

Keywords : Anti-voltage-gated potassium channel antibody syndrome, hypokalemia, hyponatremia, seizure, syndrome of inappropriate antidiuretic hormone secretion

Citation Information : Prakash S. Anti-voltage-gated potassium channel antibody syndrome: A rare cause of hyponatremia in intensive care unit. Indian J Crit Care Med 2018; 22 (10):746-748.

DOI: 10.4103/ijccm.IJCCM_480_17

License: CC BY-ND 3.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Hyponatremia causing seizure is a common cause for admission in the critical care unit. Here, we describe a peculiar case of seizure due to hyponatremia, associated with anti-voltage-gated potassium channel antibody syndrome. This case emphasizes that how a proper workup can unveil unusual but potentially treatable causes of hyponatremia. The hallmark of this syndrome is that neurological symptoms may relapse or progress if the disorder is not recognized in time. This case report emphasizes the point that how a keen observation may decode subtle signs of the grave but potentially treatable pathologies.


PDF Share
  1. Braun MM, Mahowald M. Electrolytes: Sodium disorders. FP Essent 2017;459:11-20.
  2. Bajaj BK, Shrestha S. An interesting case report of Morvan's syndrome from the Indian subcontinent. Neurol India 2007;55:67-9.
  3. Castilla-Guerra L, del Carmen Fernández-Moreno M, López-Chozas JM, Fernández-Bolaños R. Electrolytes disturbances and seizures. Epilepsia 2006;47:1990-8.
  4. Laville M, Burst V, Peri A, Verbalis JG. Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): Therapeutic decision-making in real-life cases. Clin Kidney J 2013;6:i1-20.
  5. Pillai BP, Unnikrishnan AG, Pavithran PV. Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder. Indian J Endocrinol Metab 2011;15 Suppl 3:S208-15.
  6. Huda MS, Boyd A, Skagen K, Wile D, van Heyningen C, Watson I, et al. Investigation and management of severe hyponatraemia in a hospital setting. Postgrad Med J 2006;82:216-9.
  7. Tee K, Dang J. The suspect-SIADH. Aust Fam Physician 2017;46:677-80.
  8. Newey CR, Sarwal A. Hyponatremia and voltage gated potassium channel antibody associated limbic encephalitis. J Neurol Neurophysiol 2014;5:195.
  9. Irani SR, Michell AW, Lang B, Pettingill P, Waters P, Johnson MR, et al. Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol 2011;69:892-900.
  10. Padfield PL, Morton JJ. Potassium in the syndrome of inappropriate antidiuretic hormone secretion. Postgrad Med J 1979;55:721-2.
  11. Bhatia MS, Goyal A, Saha R, Doval N. Psychogenic polydipsia-management challenges. Shanghai Arch Psychiatry 2017;29:180-3.
  12. Rickards H, Jacob S, Lennox B, Nicholson T. Autoimmune encephalitis: A potentially treatable cause of mental disorder. Adv Psychiatr Treat 2014;20:92-100.
  13. Yaxley J. Confusion, faciobrachial dystonic seizures, and critical hyponatremia in a patient with voltage-gated potassium channel encephalitis. Korean J Fam Med 2017;38:99-101.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.