Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 20 , ISSUE 12 ( 2016 ) > List of Articles


Unseen face of varicella-zoster infection in adults

Birinder Paul

Keywords : Acquired protein-S deficiency, cortical venous sinus thrombosis, deep vein thrombosis, hypercoagulability, pulmonary embolism, varicella-zoster infection

Citation Information : Paul B. Unseen face of varicella-zoster infection in adults. Indian J Crit Care Med 2016; 20 (12):731-734.

DOI: 10.4103/0972-5229.195713

License: CC BY-ND 3.0

Published Online: 01-11-2017

Copyright Statement:  Copyright © 2016; The Author(s).


Varicella infection is common in children caused by varicella-zoster virus (VZV). VZV is known to cause cerebral arterial vasculopathy and antibody-mediated hypercoagulable state leading to thrombotic complications in children. Such complications in adults are very rare. We report three cases that represent the unseen face of primary varicella infection in adults. Simultaneous involvement of cortical venous sinus thrombosis and deep vein thrombosis leading to clot in right atrium and pulmonary embolism in first case; cortical venous sinus thrombosis in second case; and deep vein thrombosis in third case. Early diagnosis and management can help prevent associated morbidity and mortality.

PDF Share
  1. Caheid Y, Husein C. Severe neurological complications of chickenpox: Report of four cases. Eur J Gen Med 2005;2:177-9.
  2. Siddiqi SA, Nishat S, Kanwar D, AH F, Azeemuddin M, Wasay M. Cerebral venous sinus thrombosis: Association with primary varicella zoster virus infection. J Stroke Cerebrovasc Dis 2012;21:917.
  3. Nagel M, Gilden D. Varicella Zoster Virus Infection: Generally Benign in Kids, Bad in Grown-ups. Clin Infec Dis 2014;58:1504-6.
  4. Sardana V, Mittal LC, Meena SR, Sharma D, Khandelwal G. Acute Venous Sinus Thrombosis after Chickenpox Infection. JAPI 2014:81-3.
  5. Josephson C, Nuss R, Jacobson L, Hacker MR, Murphy J, Weinberg A, et al. The varicella-autoantibody syndrome. Pediatr Res 2001;50:345-52.
  6. Sada S, Kammineni A, Kaniikannan MA, Afshan J. Cerebral sinus venous thrombosis: A rare complication of primary Varicella virus. Neuro India 2012;60:645-6.
  7. Menon B, Goyal R. Cerebral venous thrombosis as a complication of chicken pox. Ann Trop Med Public Health 2012;5:520-2.
  8. Sudhaker B, Dnyaneshwar MP, Jaidip CR, Rao SM. Cerebral venous sinus thrombosis (CVST) secondary to varicella induced hypercoagulable state in a adult. Intern Med Inside 2014;2:1.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.