Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 21 , ISSUE 8 ( 2017 ) > List of Articles


Hemolytic-uremic syndrome complicating acute pancreatitis

Narinder Singh, Neeru P. Aggarwal, Hardik R. Shah, Laxmi Jha, Anish Kumar

Keywords : Acute kidney injury, hemodialysis, plasmapheresis, thrombotic thrombocytopenic purpura

Citation Information : Singh N, Aggarwal NP, Shah HR, Jha L, Kumar A. Hemolytic-uremic syndrome complicating acute pancreatitis. Indian J Crit Care Med 2017; 21 (8):534-536.

DOI: 10.4103/ijccm.IJCCM_121_17

License: CC BY-ND 3.0

Published Online: 01-09-2018

Copyright Statement:  Copyright © 2017; The Author(s).


Hemolytic-uremic syndrome (HUS) is characterized by acute kidney injury with hemolytic anemia and thrombocytopenia. It has diverse etiologies, clinical manifestations, and risk factors. Acute pancreatitis as a cause of HUS is rare in adults. We report a case of 32-year-old male who presented with ethanol-induced acute pancreatitis complicated with hemolytic-uremic syndrome managed with hemodialysis and plasmapheresis.

PDF Share
  1. Swisher KK, Doan JT, Vesely SK, Kwaan HC, Kim B, Lämmle B, et al. Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Report of five patients with a systematic review of published reports. Haematologica 2007;92:936-43.
  2. Liu J, Hutzler M, Li C, Pechet L. Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS): The new thinking. J Thromb Thrombolysis 2001;11:261-72.
  3. Gasser C, Gautier E, Steck A, Siebenmann RE, Oechslin R. Hemolytic-uremic syndrome: Bilateral necrosis of the renal cortex in acute acquired hemolytic anemia. Schweiz Med Wochenschr 1955;85:905-9.
  4. Karpman D, Papadopoulou D, Nilsson K, Sjögren AC, Mikaelsson C, Lethagen S, et al. Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood 2001;97:3100-8.
  5. Tostivint I, Mougenot B, Flahault A, Vigneau C, Costa MA, Haymann JP, et al. Adult haemolytic and uraemic syndrome: Causes and prognostic factors in the last decade. Nephrol Dial Transplant 2002;17:1228-34.
  6. Remuzzi G. Hemolytic uremic syndrome: Past and present. Am J Kidney Dis 2000;36:LIV-VI.
  7. Silva VA. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome secondary to pancreatitis. Am J Hematol 1995;50:53-6.
  8. Consonni R, Falanga A, Barbui T. Further characterization of platelet-aggregating cysteine proteinase activity in thrombotic thrombocytopenic purpura. Br J Haematol 1994;87:321-4.
  9. Furlan M, Robles R, Galbusera M, Remuzzi G, Kyrle PA, Brenner B, et al. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med 1998;339:1578-84.
  10. Chang JC, Kathula SK. Various clinical manifestations in patients with thrombotic microangiopathy. J Investig Med 2002;50:201-6.
  11. Gourley BL, Mesa H, Gupta P. Rapid and complete resolution of chemotherapy-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) with rituximab. Cancer Chemother Pharmacol 2010;65:1001-4.
  12. Prowle JR, Bellomo R. Continuous renal replacement therapy: Recent advances and future research. Nat Rev Nephrol 2010;6:521-9.
  13. Fu P, Yuan AH, Wang CH, Li X, Wu HY. Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy. BMC Nephrol 2014;15:1.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.