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VOLUME 21 , ISSUE 8 ( 2017 ) > List of Articles


Hemodialysis for lactic acidosis

Ashwin K. Mani, N. Karthiraj

Keywords : Hematological malignancy, hemodialysis, hyperlactatemia, lactic acidosis, malignancy

Citation Information : Mani AK, Karthiraj N. Hemodialysis for lactic acidosis. Indian J Crit Care Med 2017; 21 (8):537-538.

DOI: 10.4103/ijccm.IJCCM_167_17

License: CC BY-ND 3.0

Published Online: 01-09-2018

Copyright Statement:  Copyright © 2017; The Author(s).


Lactic acidosis (Type A) is common in critically ill patients and usually treated by correcting the underlying etiology. We present the case of a young female who presented with life-threatening lactic acidosis secondary to hematological malignancy. Timely initiation of hemodialysis was lifesaving. The case highlights the importance of considering Type B lactic acidosis (in this case secondary to a hematological malignancy) and also initiating renal replacement therapy when routine measures are ineffective.

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  1. Warburg O, Posener K, Negelein E. Über den stoffwechsel der carcinomzelle. Biochem Z 1924;152:309-44.
  2. Mazurek S, Boschek CB, Eigenbrodt E. The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J Bioenerg Biomembr 1997;29:315-30.
  3. Werner H, LeRoith D. The role of the insulin-like growth factor system in human cancer. Adv Cancer Res 1996;68:183-223.
  4. Glasheen JJ, Sorensen MD. Burkitt's lymphoma presenting with lactic acidosis and hypoglycemia – A case presentation. Leuk Lymphoma 2005;46:281-3.
  5. Sillos EM, Shenep JL, Burghen GA, Pui CH, Behm FG, Sandlund JT. Lactic acidosis: A metabolic complication of hematologic malignancies: Case report and review of the literature. Cancer 2001;92:2237-46.
  6. Chan FH, Carl D, Lyckholm LJ. Severe lactic acidosis in a patient with B-cell lymphoma: A case report and review of the literature. Case Rep Med 2009:2009:1-6.
  7. Oriot D, Wood C, Gottesman R, Huault G. Severe lactic acidosis related to acute thiamine deficiency. JPEN J Parenter Enteral Nutr 1991;15:105-9.
  8. Block JB. Lactic acidosis in malignancy and observations on its possible pathogenesis. Ann N Y Acad Sci 1974;230:94-102.
  9. Mathieu D, Neviere R, Billard V, Fleyfel M, Wattel F. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: A prospective, controlled clinical study. Crit Care Med 1991;19:1352-6.
  10. Prikis M, Bhasin V, Young MP, Gennari FJ, Rimmer JM. Sustained low-efficiency dialysis as a treatment modality in a patient with lymphoma-associated lactic acidos. Nephrol Dial Transplant 2007;22:2383-5.
  11. Jabr FI. Lactic acidosis in patients with neoplasms: An oncologic emergency. Mayo Clin Proc 2006;81:1505-6.
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