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VOLUME 21 , ISSUE 11 ( 2017 ) > List of Articles


Influenza B virus triggering macrophage activation syndrome in an infant

K. Jayashree, Suchetha Rao, Nutan Kamath

Keywords : Bicytopenia, hyperferritinemia, hypertriglyceridemia, secondary hemophagocytic lymphohistiocytosis, thrombocytopenia

Citation Information : Jayashree K, Rao S, Kamath N. Influenza B virus triggering macrophage activation syndrome in an infant. Indian J Crit Care Med 2017; 21 (11):802-803.

DOI: 10.4103/0972-5229.218137

License: CC BY-ND 3.0

Published Online: 01-06-2012

Copyright Statement:  Copyright © 2017; The Author(s).


Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopathy. We report a 10-month-old female infant with fever, convulsions, and hepatosplenomegaly. Laboratory data of bicytopenia, low erythrocyte sedimentation rate, and elevated liver enzymes suggested MAS. This was supported by the presence of hyperferritinemia with hypertriglyceridemia. MAS was triggered by influenza B virus. She responded to treatment with immunoglobulin and steroid.

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