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VOLUME 21 , ISSUE 12 ( 2017 ) > List of Articles


Thrombocytopenia in critically ill patients: Clinical and laboratorial behavior and its correlation with short-term outcome during hospitalization

Divya Khurana, Shilpa A. Deoke

Keywords : Critically ill patients, prognostic marker, thrombocytopenia

Citation Information : Khurana D, Deoke SA. Thrombocytopenia in critically ill patients: Clinical and laboratorial behavior and its correlation with short-term outcome during hospitalization. Indian J Crit Care Med 2017; 21 (12):861-864.

DOI: 10.4103/ijccm.IJCCM_279_17

License: CC BY-ND 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; The Author(s).


Background: Thrombocytopenia, being among the most common laboratory abnormality, found in Intensive Care Unit (ICU) patients is commonly associated with sepsis and disseminated intravascular coagulation. Declining platelet counts are associated with higher mortality rates. Thus, thrombocytopenia can be used as a prognostic marker in critically ill patients. Methodology: A prospective observational study was conducted on patients fulfilling the inclusion criteria and were evaluated for complete medical history, clinical, and laboratorial examination. Short-term outcome of the patient was correlated with thrombocytopenia. Results: The incidence of thrombocytopenia in ICU patients was 37.57%, and mortality was 44%. Higher mortality rate was found among patients with acute febrile illnesses, respiratory diseases, and sepsis (P = 0.08, 0.22, 0.41 respectively). The mortality was higher in patients with platelet counts <100,000/μl (P = 0.0008) and whose platelet levels declined on day 3 or 5 (P = 0.0001). Conclusions: Low as well as declining platelet counts are markers of severity of critical patients and are directly related to prognosis and mortality of patients in ICU.

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  1. Elgohary TS, Zaghla HE, Azab AM, Hagag T. Role of thrombocytopenia as an independent prognostic marker in the critically ill patients with multiorganfailure. Med J Cairo Univ 2011;79:1-9.
  2. Chakraverty R, Davidson S, Peggs K, Stross P, Garrard C, Littlewood TJ, et al. The incidence and cause of coagulopathies in an intensive care population. Br J Haematol 1996;93:460-3.
  3. Stéphan F, Hollande J, Richard O, Cheffi A, Maier-Redelsperger M, Flahault A, et al. Thrombocytopenia in a surgical ICU. Chest 1999;115:1363-70.
  4. Crowther MA, Cook DJ, Meade MO, Griffith LE, Guyatt GH, Arnold DM, et al. Thrombocytopenia in medical-surgical critically ill patients: Prevalence, incidence, and risk factors. J Crit Care 2005;20:348-53.
  5. Akca S, Haji-Michael P, de Mendonça A, Suter P, Levi M, Vincent JL, et al. Time course of platelet counts in critically ill patients. Crit Care Med 2002;30:753-6.
  6. Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG, et al. Thrombocytopenia in patients in the medical Intensive Care Unit: Bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002;30:1765-71.
  7. Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000;28:1871-6.
  8. Boechat TD, Silveira MF, Faviere W, Macedo GL. Thrombocytopenia in sepsis: An important prognosis factor. Rev Bras Ter Intensiva 2012;24:35-42.
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