May-Thurner syndrome (MTS) or iliac vein compression syndrome is an uncommon cause of deep venous thrombosis (DVT) of the lower limb occurring, especially on the left side. It occurs due to compression of the left common iliac vein by the right common iliac artery and occurs predominantly in young females. The awareness of such a presentation is essential to guide therapy. We report one such unusual case of acute-onset DVT of the left lower limb due to MTS.
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