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VOLUME 22 , ISSUE 9 ( 2018 ) > List of Articles

RESEARCH ARTICLE

The Importance of Serial Time Point Quantitative Assessment of Cardiac Troponin I in the Diagnosis of Acute Myocardial Damage

Vidyut Jain, Arindam Bose, Girish Kawthekar, Chandrabala Chhabra, Nanda Hemvani, Dhananjay S. Chitnis

Keywords : Acute coronary syndrome, acute myocardial infarction, cardiac troponin I, non-ST-elevated MI, unstable angina

Citation Information : Jain V, Bose A, Kawthekar G, Chhabra C, Hemvani N, Chitnis DS. The Importance of Serial Time Point Quantitative Assessment of Cardiac Troponin I in the Diagnosis of Acute Myocardial Damage. Indian J Crit Care Med 2018; 22 (9):629-631.

DOI: 10.4103/ijccm.IJCCM_8_16

License: CC BY-ND 3.0

Published Online: 01-04-2015

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Objective: The present study was aimed to establish a threshold value for cardiac troponin I (cTnI) for nonacute coronary syndrome (ACS) participants from the local population and also to determine the importance of serial time point estimation of cTnI in acute myocardial infarction (AMI), non-ST-elevated MI (NSTEMI), and unstable angina cases. Methods: The present study included 194 cases, admitted in ICCU with the complaint of anginal pain; 31 were diagnosed with AMI with typical electrocardiography (ECG) changes; whereas, 48 cases were diagnosed with NSTEMI. The latter group of cases was selected for the time point study of cTnI release at 0—4 h, 6—12 h, 72 h, and 144 h of admission. cTnI levels were assessed using the Abbott ARCHITECT i1000SR system. Results: ACS was clinically ruled out in 98 cases, and cTnI level for them was used to decide cTnI threshold for the non-ACS group. cTnI level was checked in 17 cases of unstable angina. The threshold value of cTnI for non-ACS participants was 0.1 ng/ml and can be considered as cut-off value for the regional population. The data suggested that the peak of cTnI levels in most of the AMI cases reached during 6—12 h. The cTnI levels were lower than 0.1 ng/ml, and no significant change in ECG was noticed in 17 cases of unstable angina. Conclusion: The present study suggested that the repeat of cTnI assay after 4—6 h of admission is required if the initial value is <3 ng/ml.


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