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VOLUME 19 , ISSUE 3 ( 2015 ) > List of Articles


Methylmalonic acidemia mimicking diabetic ketoacidosis and septic shock in infants

Ashwini Malhotra, Navdeep Saini, Sunny Chhabra

Keywords : Anion gap, metabolic acidosis, methylmalonic acidemia

Citation Information : Malhotra A, Saini N, Chhabra S. Methylmalonic acidemia mimicking diabetic ketoacidosis and septic shock in infants. Indian J Crit Care Med 2015; 19 (3):183-185.

DOI: 10.4103/0972-5229.152776

License: CC BY-ND 3.0

Published Online: 01-02-2016

Copyright Statement:  Copyright © 2015; The Author(s).


Methylmalonic acidemia (MMA) is most common inherited type of organic acidemia. It has diverse presentation in older infants without any initial apparent symptoms. MMA sometimes present with sudden metabolic decompensation, which may mimics common emergencies like septic shock and diabetic ketoacidosis (DKA) without early recognition can be fatal. In born error of metabolism especially organic acidemia should be suspected in any infant presented with severe high anion gap metabolic acidosis. We report two cases of MMA in infants presented acutely mimicking DKA and septic shock.

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