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VOLUME 19 , ISSUE 7 ( 2015 ) > List of Articles


Sepsis of unknown origin with multiorgan failure syndrome: Think of hemophagocytic lymphohistiocytosis

Amit Kumar Mandal, Namrata Maheshwari

Keywords : Hemophagocytic lymphohistiocytosis, macrophages, multiorgan failure, sepsis

Citation Information : Mandal AK, Maheshwari N. Sepsis of unknown origin with multiorgan failure syndrome: Think of hemophagocytic lymphohistiocytosis. Indian J Crit Care Med 2015; 19 (7):419-421.

DOI: 10.4103/0972-5229.160291

License: CC BY-ND 3.0

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2015; The Author(s).


Hemophagocytic lymphohistiocytosis is a clinic pathologic entity characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. It is a potentially lethal disorder due to an uncontrolled immune response to a triggering agent. HPS may be primary, or secondary to malignancy, infections, auto-immune diseases, and pharmacotherapy. HPS is a rare, but life-threatening complication. Herein, we described a female patient with HPS with secondary sepsis. Our objective was to raise the importance of early diagnosis of HFS by presenting a representative case.

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