Citation Information :
Dube P, Saroa R, Palta S. Coinfections in Intensive Care Unit with pulmonary tuberculosis and mucormycosis: A clinical dilemma. Indian J Crit Care Med 2016; 20 (3):191-193.
Herein, we present the case report of an adult male diabetic patient who had coinfection with Mycobacterium tuberculosis and mucormycosis, which otherwise is a rare clinical entity. Diabetes mellitus may predispose a patient to tuberculosis (TB) infection which further weakens immune system thus making him susceptible to other fungal or bacterial infections which may pose various treatment difficulties. Therefore, there is a need for mycological and bacteriological investigations in patients with pulmonary TB to rule out secondary coinfections thus contributing to better management.
Mwaura EN, Matiru V, Bij C. Mycological finding of sputum samples from pulmonary tuberculosis patients attending TB clinic in Nairobi, Kenya. Virol Mycol 2013;2:119.
Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: Human fungal infections. Sci Transl Med 2012;4:165rv13.
Greenberg RN, Scott LJ, Vaughn HH, Ribes JA. Zygomycosis (mucormycosis): Emerging clinical importance and new treatments. Curr Opin Infect Dis 2004;17:517-25.
Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis pathophysiology, presentation, and management. Clin Microbiol Rev 2005;18:556-69.
Collaborative Framework for Care and Control of Tuberculosis and Diabetes. The Stop TB Department: WHO; 2011. Available from: http://www.who.int/diabetes/publications/tb_diabetes2011/en/index.html. [Last accessed on 2015 Jul 15].
Garg R, Marak RS, Verma SK, Singh J, Sanjay, Prasad R. Pulmonary mucormycosis mimicking as pulmonary tuberculosis: A case report. Lung India 2008;25:129-31.
Machida M, Gomi K. Aspergillus: Molecular Biology and Genomics. UK: Caister Academic Press; 2010. p. 173-98.
Sharma SK, Agarwal N, Mukherjee A, Seth T, Mishra P, Xess I, et al. Coexisting pulmonary tuberculosis and mucormycosis in a patient with aplastic anemia post allogenic stem cell transplantation. Mediterr J Hematol Infect Dis 2011;3:e2011036.
Aggarwal D, Chander J, Janmeja AK, Katyal R. Pulmonary tuberculosis and mucormycosis co-infection in a diabetic patient. Lung India 2015;32:53-5.
Petrikkos G, Drogari-Apiranthitou M. Zygomycosis in immunocompromised non-haematological patients. Mediterr J Hematol Infect Dis 2011;3:e2011012.
