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VOLUME 20 , ISSUE 5 ( 2016 ) > List of Articles

CASE REPORT

Statin-induced rhabdomyolysis in patient with renal failure and underlying undiagnosed hypothyroidism

Sachinkumar N. Ambapkar, Naresh Shetty, Arpita Dwivedy, Harshad Onkarrao Malve

Keywords : Atorvastatin, foot drop, myopathy, myositis

Citation Information : Ambapkar SN, Shetty N, Dwivedy A, Malve HO. Statin-induced rhabdomyolysis in patient with renal failure and underlying undiagnosed hypothyroidism. Indian J Crit Care Med 2016; 20 (5):305-307.

DOI: 10.4103/0972-5229.182210

License: CC BY-ND 3.0

Published Online: 01-05-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Rhabdomyolysis is a syndrome characterized by muscle necrosis which causes the release of myoglobin into the bloodstream. The manifestations of this syndrome range from asymptomatic elevation of serum muscle enzymes to life-threatening cases associated with extremely high enzyme levels, electrolyte imbalance, and acute renal failure. Symptoms of rhabdomyolysis include dark urine, muscle weakness, and fatigue. Statins are commonly used drugs for the prevention and management of dyslipidemia. We present an interesting and critical case on statin-induced rhabdomyolysis with renal failure and previously undiagnosed idiopathic hypothyroidism.


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  1. Jukema JW, Cannon CP, de Craen AJ, Westendorp RG, Trompet S. The controversies of statin therapy: Weighing the evidence. J Am Coll Cardiol 2012;60:875-81.
  2. Mendes P, Robles PG, Mathur S. Statin-induced rhabdomyolysis: A comprehensive review of case reports. Physiother Can 2014;66:124-32.
  3. Holder K. Myalgias and myopathies: Drug-induced myalgias and myopathies. FP Essent 2016;440:23-7.
  4. Päivä H, Thelen KM, Van Coster R, Smet J, De Paepe B, Mattila KM, et al. High-dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial. Clin Pharmacol Ther 2005;78:60-8.
  5. Bruckert E, Hayem G, Dejager S, Yau C, Bégaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients – the PRIMO study. Cardiovasc Drugs Ther 2005;19:403-14.
  6. Harper CR, Jacobson TA. Evidence-based management of statin myopathy. Curr Atheroscler Rep 2010;12:322-30.
  7. Dedhia V, Munsi SC. Myopathy caused by a combination rosuvastatin and fenofibrate. J Assoc Physicians India 2007;55:152-3.
  8. Bays H. Statin safety: An overview and assessment of the data-2005. Am J Cardiol 2006;97:6C-26C.
  9. Choi HK, Won EK, Choungsss SY. Effect of coenzyme Q10 supplementation in statin-treated obese rats. Biomol Ther (Seoul) 2016;24:171-7.
  10. Chaudhary N, Duggal AK, Makhija P, Puri V, Khwaja GA. Statin-induced bilateral foot drop in a case of hypothyroidism. Ann Indian Acad Neurol 2015;18:331-4.
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