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VOLUME 20 , ISSUE 7 ( 2016 ) > List of Articles


The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal

Saurabh Pradhan, Ashish Ghimire, Balkrishna Bhattarai, Bashudha Khanal, Krishna Pokharel, Madhab Lamsal, Sidhhartha Koirala

Keywords : C-reactive protein, diagnosis, sepsis

Citation Information : Pradhan S, Ghimire A, Bhattarai B, Khanal B, Pokharel K, Lamsal M, Koirala S. The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal. Indian J Crit Care Med 2016; 20 (7):417-420.

DOI: 10.4103/0972-5229.186226

License: CC BY-ND 3.0

Published Online: 01-02-2014

Copyright Statement:  Copyright © 2016; The Author(s).


Aim: C-reactive protein (CRP) is a commonly used biomarker of sepsis, the leading cause of mortality in Intensive Care Units (ICUs). However, sufficient data are still lacking to strongly recommend it in clinical practice. The present study is aimed to find out its reliability in diagnosing sepsis. Materials and Methods: CRP was measured in ICU-admitted patients with systemic inflammatory response syndrome and compared using a cutoff of 50 mg/L with the gold standard for diagnosing sepsis, taken as isolation of organism from a suspected source of infection or the Centers for Disease Control criteria for clinical sepsis. Results: CRP had a sensitivity and specificity of 84.3% and 46.15%, respectively. Area under the receiver operating characteristics curve was calculated to be 0.683 (±0.153, P < 0.05). The cutoff value with the best diagnostic accuracy was found to be 61 mg/L. Conclusion: CRP is a sensitive marker of sepsis, but it is not specific.

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