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VOLUME 20 , ISSUE 9 ( 2016 ) > List of Articles


Systematic review of statins in sepsis: There is no evidence of dose response

Sandeep Gudibande, Tony Whitehouse, Catherine Snelson, Tonny Veenith, Morgan Quinn, Claire Moody, Bill Tunnicliffe, Zahid Khan, Mav Manji, Nick Murphy

Keywords : High dose, mortality, low dose, sepsis, statin

Citation Information : Gudibande S, Whitehouse T, Snelson C, Veenith T, Quinn M, Moody C, Tunnicliffe B, Khan Z, Manji M, Murphy N. Systematic review of statins in sepsis: There is no evidence of dose response. Indian J Crit Care Med 2016; 20 (9):534-541.

DOI: 10.4103/0972-5229.190366

License: CC BY-ND 3.0

Published Online: 01-03-2014

Copyright Statement:  Copyright © 2016; The Author(s).


Objectives: Sepsis is a common cause of morbidity and mortality and is associated with significant costs to the healthcare organizations. We performed a systematic review and meta-analysis to assess whether high or low-dose statin therapy improved mortality in patients with sepsis. Methods: The trials analyzed in this study were multicenter or single center randomized control studies using statins for sepsis in a hospital setting. The patients included were adults with suspected or confirmed infection. Interventions: This study found eight randomized controlled trials where participants were given either a statin or placebo daily for 14–28 days, the duration of their illness, or until their death or discharge, which ever occurred first. Primary and Secondary Outcomes Measured: This meta-analysis measured the effect of statin therapy on in hospital and 28 days mortality. Results: In unselected patients, there was no demonstrable difference in the 28 days mortality (relative risk [RR] 0.88 95% confidence interval [CI], 0.70–1.12 and P = 0.16). There was also no significant difference between statin versus placebo for in-hospital mortality (RR 0.98 95% CI, 0.85–1.14 P = 0.36). When the studies where divided into low-dose and high-dose groups, there were no statistically significant differences for in-hospital mortality between low-dose statin versus placebo for (RR 0.81 CI 0.44–1.49 P = 0.27) or high-dose statin versus placebo (RR 0.99 95% CI 0.85–1.16, P = 0.28). There was no significant difference in adverse effects between the high- and low-dose groups. Conclusions: In this meta-analysis, we found that the use of statins did not significantly improve either in-hospital mortality or 28-day mortality in patients with sepsis. In the low-dose group, there were fewer quality multicenter studies; hence, conclusions based on the results of this subgroup are limited.

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