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VOLUME 18 , ISSUE 5 ( May, 2014 ) > List of Articles


Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series

Annil Mahajan, Vivek Mahajan, Vishal R. Tandon, Vijay Khajuria, Zahid Gillani, Vijant Chandail

Keywords : Adverse drug reactions, drug safety, fatal ADR, mortality

Citation Information : Mahajan A, Mahajan V, Tandon VR, Khajuria V, Gillani Z, Chandail V. Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series. Indian J Crit Care Med 2014; 18 (5):315-319.

DOI: 10.4103/0972-5229.132499

License: CC BY-ND 3.0

Published Online: 01-07-2005

Copyright Statement:  Copyright © 2014; The Author(s).


Medical burden of fatal adverse drug reactions (FADRs) is significant. The epidemiological data on FADR do exist from the western world, but there is scanty from India. We hereby report a case series of FADRs recorded in a 2 years period. Point prevalence of FADRs was 0.223%. Point prevalence of all cause death in the hospital was 1.20%. The drugs causing FADRs were injection bupivacaine, amphotericin B, directly observed treatment short-course Category-1, injection streptokinase, and tablet ferrous sulfate. All these FADR were labeled as possible expect one case as probable. All FADR were labeled as type A. In three out of five the central nervous system was involved, while the hepatic system and multiorgan failure accounted for one case each. Two cases each were acute and subacute, while one was latent in nature. Reporting of FADRs shall go a long way in patient safety.

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