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VOLUME 9 , ISSUE 1 ( January, 2005 ) > List of Articles


Recombinant activated factor VII for acute intracerebral hemorrhage

Sudhir Kumar

Citation Information : Kumar S. Recombinant activated factor VII for acute intracerebral hemorrhage. Indian J Crit Care Med 2005; 9 (1):11-13.

DOI: 10.4103/0972-5229.16262

License: CC BY-ND 3.0

Published Online: 01-09-2009

Copyright Statement:  Copyright © 2005; The Author(s).


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  9. Friederich PW, Henny CP, Messelink EJ, Geerdink MG, Keller T, Kurth KH, et al. Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: A double-blind placebo-controlled randomised trial. Lancet 2003;361:201-5.
  10. Lindley CM, Sawyer WT, Macik BG, Lusher J, Harrison JF, Baird-Cox K, et al. Pharmacokinetics and pharmacodynamics of recombinant factor VIIa. Clin Pharmacol Ther 1994;55:638-48.
  11. He S, Blomback M, Ekman GJ, Hedner U. The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII/FIX. J Thromb Haemost 2003;1:1215-9.
  12. Sorensen B, Johansen P, Nielsen GL, Sorensen JC, Ingerslev J. Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: Clinical and biochemical aspects. Blood Coagul Fibrinolysis 2003;14:469-77.
  13. Schmidt ML, Gamerman S, Smith HE, Scott JP, DiMichele DM. Recombinant activated factor VII (rFVIIa) therapy for intracranial hemorrhage in hemophilia. A patients with inhibitors. Am J Hematol 1994;47:36-40.
  14. Arkin S, Cooper HA, Hutter JJ, Miller S, Schmidt ML, Seibel NL, et al. Activated recombinant human coagulation factor VII therapy for intracranial hemorrhage in patients with hemophilia A or B with inhibitors. Results of the novoseven emergency-use program. Haemostasis 1998;28:93-8.
  15. Vidarsson B, Onundarson PT. Recombinant factor VIIa for bleeding in refractory thrombocytopenia. Thromb Haemost 2000;83: 634-5.
  16. No authors listed. Use of recombinant activated factor VII (NovoSeven) in treatment of patients with idiopathic thrombocytopenic purpura complicated with subarachnoid and parenchimatous hemorrhage. Lik Sprava 2004;7:77-81.
  17. Carrick MM, Tyroch AH, Youens CA, Handley T. Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: Support for serial laboratory examination. J Trauma 2005;58:725-30.
  18. Morenski JD, Tobias JD, Jimenez DF. Recombinant activated factor VII for cerebral injury-induced coagulopathy in pediatric patients. Report of three cases and review of the literature. J Neurosurg 2003;98:611-6.
  19. Worth LL, Hoots WK. Development of a subdural vein thrombosis following aggressive factor VII replacement for postnatal intracranial haemorrhage in a homozygous factor VII-deficient infant. Haemophilia 1998;4:757-61.
  20. NovoSeven prescribing information. information.asp (accessed on March 17, 2005)
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