Massive lower gastrointestinal (GI) hemorrhage is a rare manifestation of GI cytomegalovirus (CMV) infection, in a critically ill patient. We report a 69-year-old man, known to have chronic obstructive pulmonary disease on ventilator, who developed sudden onset abdominal pain and massive lower GI bleeding. Due to uncontrolled bleeding, the patient was explored surgically. Bleeding from ileum was evident. The affected segment of the ileum was resected. Histology confirmed the diagnosis of CMV enteritis and Gancyclovir was initiated. On the following days, his physical state had improved and bleeding was resolved.
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