Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 10 , ISSUE 4 ( October, 2006 ) > List of Articles

RESEARCH ARTICLE

Correlation of mixed venous and central venous oxygen saturation and its relation to cardiac index

Devi Prasad Hegde, G. N. Kumaraswamy, Ratan Gupta, T. N. Girish

Keywords : Cardiac index, central venous oxygen saturation, mixed venous oxygen saturation, shock

Citation Information : Hegde DP, Kumaraswamy GN, Gupta R, Girish TN. Correlation of mixed venous and central venous oxygen saturation and its relation to cardiac index. Indian J Crit Care Med 2006; 10 (4):230-234.

DOI: 10.4103/0972-5229.29841

License: CC BY-ND 3.0

Published Online: 01-10-2010

Copyright Statement:  Copyright © 2006; The Author(s).


Abstract

Background and Aim: The clinical applicability of substitution of central venous oxygen saturation for mixed venous oxygen saturations in monitoring global tissue hypoxia is still a matter of controversy. Hence aim of the study is comparison of paired samples of mixed venous and central venous oxygen saturation and comparison in relation to cardiac index in varying hemodynamic conditions. Materials and Methods: Prospective clinical observation: Postoperative cardiac surgical ITU: 60 adult patients, >18 years of age of either sex: A PAC was inserted through ® IJV, triple lumen catheter was inserted through ® IJV. Blood samples were taken from distal tip of PAC and central venous catheters. An arterial blood sample was drawn from either radial or femoral arterial line. Measurements: Continuous cardiac output monitoring. Analysis of blood samples for hemoglobin concentration and oxygen saturation. Mixed venous oxygen saturations and central venous oxygen saturations were compared. The study was carried over a period of 30h in the postoperative period and samples were taken at 6h intervals. Patients were classified into three groups as follows depending on the CI: Low (< 2.5 L/m 2), medium (2.5-4 L/m 2), high (> 4 L/m2) and correlated with Svo 2 and Scvo 2. Results: 298 Comparative sets of samples were obtained. Svo 2 was consistently lower than Scvo 2 throughout the study period. The difference was statistically significant. By using Bland - Altman plot, the mean difference between Svo 2 and Scvo 2 (Svo 2 -Scvo 2) was - 2.9% ± 5.14 and confidence limits are + 7.17% and - 12.97%. The co-efficient r is > 0.7 throughout the study period for all paired samples. The correlation Svo 2 and Scvo 2 with cardiac index in all the three groups were >0.7. Conclusion: Scvo 2 and Svo 2 are closely related and are interchangeable. Even though individual values differ trends in Scvo2 may be substituted for trend in Svo 2


PDF Share
  1. Scheinman MM, Brown MA, Rapaport E. Critical assessment of use of central venous oxygen saturation as a mirror of mixed venous oxygen in severely ill cardiac patients. Circulation 1969;40:165-72.
  2. Lee J, Wright F, Barber R, Stanley L. Central venous oxygen saturation in shock: A study in man. Anesthesiology 1972;36:472-8.
  3. Berridge JC. Influence of cardiac output on the correlation between mixed venous and central venous oxygen saturation. Br J Anaesth 1992;69:409-10.
  4. Ladakis C, Myrianthefs P, Karabinis A, Karatzas G, Dosios T, Fildissis G, et al. Central venous and mixed venous oxygen saturation in critically ill patients. Respiration 2001;68:279-85.
  5. Dueck MH. Trends but not individual values of central venous oxygen saturation agree with mixed venous oxygen saturation during varying hemodynamic conditions. Anaesthesiology 2005;249-57.
  6. Reinhart K, Rudolph T, Bredle DL, Hannemann L, Cain SM. Comparison of central-venous to mixed-venous oxygen saturation during changes in oxygen supply/demand. Chest 1989;95:1216-21.
  7. Reinhart K, Kuhn HJ, Hartog C, Bredle DL. Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill. Intensive Care Med 2004;30:1572-8.
  8. Tahvanainen J, Meretoja O, Nikki P. Can central venous blood replace mixed venous blood samples? Crit Care Med 1982;10:758-61.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.