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VOLUME 11 , ISSUE 2 ( April, 2007 ) > List of Articles

REVIEW ARTICLE

Acute ingestion of copper sulphate: A review on its clinical manifestations and management

Kavitha Saravu, Jimmy Jose*, Mahadeva N. Bhat**, Beena Jimmy*, B.A. Shastry

Keywords : Acute ingestion, copper sulphate, poisoning

Citation Information : Saravu K, Jose* J, Bhat** MN, Jimmy* B, Shastry B. Acute ingestion of copper sulphate: A review on its clinical manifestations and management. Indian J Crit Care Med 2007; 11 (2):74-80.

DOI: 10.4103/0972-5229.33389

License: CC BY-ND 3.0

Published Online: 01-01-2011

Copyright Statement:  Copyright © 2007; The Author(s).


Abstract

Ingestion of copper sulphate is an uncommon mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. In severe cases methemoglobinemia needs treatment. Mortality is quite high in severe cases. A comprehensive review of the clinical presentation and management of copper sulphate poisoning is done.


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  1. Copper. J Toxicol Clin Toxicol 1999;37:217-30.
  2. Acute copper sulphate poisoning with special reference to its management with corticosteroid therapy. J Assoc Physicians India 1962;10:287-92.
  3. Accidental poisoning in infancy and childhood. J Indian Med Assoc 1967;48:20-5.
  4. Blue lips, coma and haemolysis. J Paediatr Child Health 2003;39:67-8.
  5. Gastric injury following copper sulphate ingestion. Pediatr Emerg Care 1999;15:429-31.
  6. Acute copper intoxication. Am J Dis Child 1977;131:149-51.
  7. Role of albumin-enriched peritoneal dialysate in acute copper poisoning. J Pediatr 1978;92:955-7.
  8. Acute copper sulfate poisoning. Am J Med 1965;39:849-54.
  9. Acute copper sulphate poisoning. J Assoc Physicians India 1963;11:93-103.
  10. Hepatic derangements (biochemical) in acute copper sulphate poisoning. J Indian Med Assoc 1970;55:341-2
  11. Changing trends in acute renal ailure in Third-world countries - Chandigarh study. Q J Med 1989;73:1117-23.
  12. Changing trends in acute poisoning in Chandigarh zone: A 25 year autopsy experience from a tertiary care hospital in northern India. Am J Forensic Med Pathol 1999;20:203-10.
  13. Spectrum of unnatural fatalities in the Chandigarh zone of north-west India-a 25 year autopsy study from a tertiary care hospital. J Clin Forensic Med 2003;10:145-52.
  14. In: Ellenhorn MJ. Ellenhorn′s Medical Toxicology: Diagnosis and treatment of human poisoning. 2 nd ed. Williams and Wilkins: Maryland; 1997. p. 1554-6.
  15. Copper metabolism. Am J Clin Nutr 1969;22:887-92.
  16. An unusual skin exposure to copper: Clinical and pharmacokinetic evalution. Clin Toxicol 1988;26:371-80.
  17. Copper. In: Goldfrank LR, Flomenbaum NE, Lewin NA, editors. Goldfrank′s toxicologic emergencies, 7 th ed. McGraw-Hill: New York; 2002. p. 1262-71.
  18. Copper sulphate poisoning and acute renal failure. Int J Artif Organs 1989;12:610.
  19. Biochemical changes in Blood in cases of acute copper sulphate poisoning. J Indian Med Assoc 1968;50:549-54.
  20. A study of erythrocytic glutathione in acute copper sulphate poisoning. Indian J Pathol Bacteriol 1966;9:155-62.
  21. Acute Renal Failure and Methaemoglobinaemia due to copper sulphate poisoning. J Postgrad Med 1976;22:180-4.
  22. Redox state in liver mitochondria in acute copper sulfate poisoning. Life Sci 1994;54:967-74.
  23. Study of whole blood, red cell and plasma copper levels in acute copper sulphate poisoning and their relationship with complications and prognosis. J Assoc Physicians India 1976;24:153-8.
  24. Copper-binding protein in acute copper poisoning. Forens Sci Int 1988;38:3-11.
  25. Acute renal failure following copper sulphate intoxication. Postgrad Med J 1977;53:18-23.
  26. Copper sulphate poisoning - Its impact on Kidneys. J Indian Med Assoc 1985;83:108-10.
  27. Acute copper sulphate poisoning. J Postgrad Med 1968;14:38-41.
  28. Acute copper sulfate poisoning with jaundice. J Ir Med assoc 1969;62:99-100.
  29. Spectrum of poisoning requiring haemodialysis in tertiary care hospital in India. Int J Artif Organs 1993;16:20-2.
  30. Methaemoglobinemia. In: Goldfrank LR, Flomenbaum NE, Lewin NA, editors. Goldfrank′s toxicologic emergencies, 7 th ed. McGraw-Hill: New York; 2002. p. 1438-49.
  31. Cupric sulfate intoxication with rhabdomyolysis, treated with chelating agents and blood purification. Intern Med 2000;39:253-5.
  32. Massive copper sulfate ingestion resulting in hepatotoxicity. J Toxicol Clin Toxicol 1985;22:585-8.
  33. Methylene Blue. In: Goldfrank LR, Flomenbaum NE, Lewin NA, editors. Goldfrank′s toxicologic emergencies, 7 th ed. McGraw-Hill: New York, USA; 2002. p. 1450-1.
  34. A study of serum ceruloplasmin levels in acute copper sulphate poisonings. J Assoc Physicians India 1978;26:983-7.
  35. The emergency management of caustic ingestions. Emerg Med Clin North Am 1984;2:77-86.
  36. Histopathologic evaluation of the therapeutic efficacy of water and milk dilution for esophageal acid injury. Acad Emerg Med 1995;2:587-91.
  37. Caustics and batteries. In: Goldfrank LR, Flomenbaum NE, Lewin NA, editors. Goldfrank′s toxicologic emergencies, 7 th ed. McGraw-Hill: New York; 2002. p. 1326.
  38. Position statement: Single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol 1997;35:721-41.
  39. Poison treatment drug product for over-the-counter human use: Tentative final monograph. FDA: Fed Register 1985;50:2244-62.
  40. Caustic ingestions: Symptoms as predictors of esophageal injury. Am J Dis Child 1984;138:863-5.
  41. Is esophagogastroduodenoscopy necessary in all caustic ingestions? J Pediatr Gastroenterol Nutr 2001;32:50-3.
  42. New therapeutic approach to corrosive burns of the gastrointestinal tract. Gut 1980;21:370-5.
  43. Corrosive acid ingestion in man - a clinical and endoscopic study. Gut 1984;25:183-7.
  44. Sucralfate therapy for acid-induced upper gastrointestinal tract injury. Am J Gastroenterol 1989;84:204-5.
  45. In: Ellenhorn MJ. Ellenhorn′s Medical Toxicology: Diagnosis and treatment of human poisoning. 2 nd ed. Williams and Wilkins: Maryland; 1997. p. 1496-9.th
  46. Arthritis and musculoskeletal disorders. In: Tierney LM, Mc Phee SJ, Papadakis MA, editors. Current medical diagnosis and treatment. 45 th ed. McGraw Hill′s: New York; 2006. p. 843-4.
  47. Accidental ingestion of a zinc and copper sulfate preparation. J Toxicol Clin Toxicol 1996;34:724-30.
  48. Elevation of serum copper following copper sulfate as an emetic. Pediatrics 1968;42:189-93.
  49. The Pediatric Drug Handbook, 3 rd ed. Mosby-Year Book Inc: St. Louis, MO; 1995.
  50. Copper sulfate-induced hemolytic anemia. Inhibition of glucose-6-phosphate dehydrogenase and other possible etiologic mechanisms. Arch Intern Med 1967;120:428-32.
  51. Ineffectiveness of hemodialysis in copper sulphate poisoning. Nephron 1975;15:74-7.
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