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VOLUME 15 , ISSUE 3 ( July, 2011 ) > List of Articles


Genetic predisposition to oxcarbazepine induced Stevens-Johnson syndrome

Pranay Wal, Ankita Wal, Umeshwar Pandey, Awani K. Rai, Anil Bhandari

Keywords : Hypersensitivity, oxcarbazepine, Stevens-Johnson syndrome

Citation Information : Wal P, Wal A, Pandey U, Rai AK, Bhandari A. Genetic predisposition to oxcarbazepine induced Stevens-Johnson syndrome. Indian J Crit Care Med 2011; 15 (3):173-175.

DOI: 10.4103/0972-5229.84904

License: CC BY-ND 3.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2011; The Author(s).


Stevens-Johnson syndrome (SJS) is a rare immunologic reaction that may involve skin or various mucosal surfaces. The etiology may range from multiple pharmacologic agents to viral infections. Associated findings can range from minimal skin and mucosal involvement to extensive dermal exfoliation, nephritis, lymphadenopathy, hepatitis, and multiple serologic abnormalities. We report a female patient of 38 years with a history of drug allergy who was administered oxcarbazepine for the management of right partial bronchial seizure due to left parasagittal mass lesion following which she developed papular rashes all over the body and diagnosed as SJS. Although carbamazepine (CBZ) is the most common cause of SJS, a new anticonvulsant, oxcarbazepine, which is structurally related to CBZ, has been shown to induce SJS.

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  1. Rawlins MD, Thompson JW. Mechanisms of adverse drug reactions. In: Davies DM, editor. Textbook of Adverse Drug Reactions. Oxford, UK: Oxford University Press; 1991. p. 18-45.
  2. Demoly P, Gomes ER. Drug hypersensitivities: Definition, epidemiology and risk factors. Eur Ann Allergy Clin Immunol 2005;37:202-6.
  3. Pirmohamed M, Park BK. Genetic susceptibility to adverse drug reactions. Trends Pharmacol Sci 2001;22:298-305.
  4. Vittorio CC, Muglia JJ. Anticonvulsant hypersensitivity syndrome. Arch Intern Med 1995;155:2285-90
  5. Frisch PO, Ruiz-Maldonado R. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrosis. In: Freedberg IM, Eisen AZ, Wolff K, editors. Fitzpatrick′s Dermatology in General Medicine. 6 th ed. New York: McGraw-Hill; 2003. p. 543-57.
  6. Calligaris L, Stocco G, Lubicibus SD, Marino S, Decorti G, Barbi E, et al. Carbamazepine hypersensitivity syndrome triggered by a human herpes virus reactivation in a genetically predisposed patient. Int Arch Allergy Immunol 2009;149:173-7.
  7. Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, et al. Medical genetics: A marker for Stevens-Johnson syndrome. Nature 2004;428:486.
  8. Halevy S, Ghislain PD, Mockenhaupt M, Fagot JP, Bouwes-Bavinck JN, Sidoroff A, et al. Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J Am Acad Dermatol 2008;58:25-32
  9. Lam NS, Yang YH, Wang LC, Lin YT, Chiang BL. Clinical characteristics of childhood erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in Taiwanese children. J Microbiol Immunol Infect 2004;37:366-70.
  10. Yang G, Deng YJ, Qin H, Zhu BF, Chen F, Shen CM, et al. HLA-BFNx0115 subtypes distribution in Han population in Beijing, China, as compared with those of other populations. Int J Immunogenet 2010;37:205-12.
  11. Chen YC, Chu CY, Hsiao CH. Oxcarbazepine-induced Stevens-Johnson syndrome in a patient with HLA-BFNx011502 genotype. J Eur Acad Dermatol Venereol 2009;23:702-3.
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