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VOLUME 16 , ISSUE 3 ( July, 2012 ) > List of Articles


Continuous versus intermittent administration of piperacillin-tazobactam in intensive care unit patients with ventilator-associated pneumonia

Fanak Fahimi, Hamidreza Jamaati, Seyed Mohammad Hashemian, Arvin Najafi, Somayeh Ghafari, Payam Tabarsi, Arnavaz Akhzarmehr

Keywords : Piperacillin, tazobactam, ventilator-associated pneumonia

Citation Information : Fahimi F, Jamaati H, Hashemian SM, Najafi A, Ghafari S, Tabarsi P, Akhzarmehr A. Continuous versus intermittent administration of piperacillin-tazobactam in intensive care unit patients with ventilator-associated pneumonia. Indian J Crit Care Med 2012; 16 (3):141-147.

DOI: 10.4103/0972-5229.102083

License: CC BY-ND 3.0

Published Online: 01-07-2012

Copyright Statement:  Copyright © 2012; The Author(s).


Background and Aims: Ventilator-associated pneumonia (VAP) is one of the most common Intensive Care Unit (ICU)-acquired infection. The aim of this study was to compare the clinical outcome of continuous and intermittent administration of piperacillin-tazobactam by serial measurements of the Clinical Pulmonary Infection Score (CPIS). Subjects and Methods: Groups were designed as parallel and the study was designed as quasi-experimental and conducted at a semi-closed ICU between September 2008 and May 2010. Patients received 3.375 g (piperacillin 3 g/tazobactam 0.375 g) either through intermittent infusion every 6 h for 30 min [Intermittent Infusion (II) group; n = 30] or through continuous infusion every 8 h for 4 h [Continuous Infusion (CI) group; n = 31]. CPIS was used to assess the clinical diagnosis and outcome of VAP patients. Results: Sex, age, Acute Physiology and Chronic Health Evaluation II II score on ICU admission, diagnosis and underlying disease of VAP patients were not significantly different in the CI (n = 31) and II (n = 30) groups. Duration of mechanical ventilation, length of stay, total number of antibiotics used per patient and duration of piperacillin/tazobactam treatment were similar in both groups. Mortality rates of VAP patients were similar between both groups during hospitalization. Conclusion: There was no significant difference in clinical outcomes of patients receiving piperacillin-tazobactam via CI or II when measured by serial CPIS score.

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