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VOLUME 23 , ISSUE 4 ( April, 2019 ) > List of Articles

ORIGINAL ARTICLE

Identification and Assessment of Potential Drug–Drug Interactions in Intensive Care Unit Patients

Bhavika Ravindra Wagh, Deepa Dhananjay Godbole, Shubham Shivaji Deshmukh, Shivakumar Iyer, Prasanna R Deshpande

Keywords : Intensive care unit, Monitoring and assessment, Potential drug–drug interaction

Citation Information : Wagh BR, Godbole DD, Deshmukh SS, Iyer S, Deshpande PR. Identification and Assessment of Potential Drug–Drug Interactions in Intensive Care Unit Patients. Indian J Crit Care Med 2019; 23 (4):170-174.

DOI: 10.5005/jp-journals-10071-23147

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Context: Intensive care unit (ICU) patients suffer from various comorbidities and usually receive complex pharmacotherapy which increases the risk of drug–drug interactions (DDIs). Aim: To identify and assess potential DDIs (pDDIs) in ICU patients. Settings and design: A prospective observational study conducted in ICU of a tertiary care hospital for a period of 6 months. Materials and methods: Patient information was noted in the data collection form and pDDIs were assessed using Micromedex® database. Statistical analysis used: Chi-square test was used to find correlation of pDDIs with patient parameters. p value was calculated keeping the significance level 0.05. Results: Total 400 subjects were included; having an average age of 55.99 ± 15.62 years with a higher percentage of males (61.75%). About 305 (76.25%) patients were found with pDDIs, showing an average of 2.93 pDDIs/patient. The findings of this study were as follows: Total interactions = 1171, contraindicated = 6 (1%), major = 715 (61%), moderate = 428 (36%), and minor = 22 (2%) pDDIs. Further, majority of pDDIs had onset of action “not specified”; documentation “fair” and probable mechanism “pharmacodynamic” in nature. Significant association of occurrence of pDDIs was found with number of drugs prescribed to patients in ICU. Conclusion: This study demonstrated a high prevalence of pDDI in ICU due to the complexity of pharmacotherapy which showed major pDDIs as the most evident (61%) while contraindicated were 1%. Further studies are needed to better explore this area which may help in realizing the goal of good clinical practice and may offer a methodology to further increase drug safety.


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