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VOLUME 23 , ISSUE 4 ( April, 2019 ) > List of Articles


Fulminant Histoplasmosis Presenting as Pyrexia of Unknown Origin in Immunocompetent Adult Diabetic Patient

Prakash Shastri, Pallav Gupta

Keywords : Bone marrow, Histoplasmosis, Immunocompetent

Citation Information : Shastri P, Gupta P. Fulminant Histoplasmosis Presenting as Pyrexia of Unknown Origin in Immunocompetent Adult Diabetic Patient. Indian J Crit Care Med 2019; 23 (4):193-195.

DOI: 10.5005/jp-journals-10071-23154

License: CC BY-NC 4.0

Published Online: 01-03-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Opportunistic infections are commonly seen in immunocompromised individuals such as those suffering from HIV infection, organ transplant recipients and connective tissue disorders. Histoplasmosis is one of the fungal opportunistic infections which is usually seen in immunosuppressed individuals but can also be seen in immunocompetent patients with frequent involvement of adrenal glands. We present a case of adult diabetic patient presenting as pyrexia of unknown origin in which bone marrow aspiration and biopsy lead to diagnosis of histoplasmosis without adrenal involvement.

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  1. Harnalikar M, Kharkar V, et al. Disseminated cutaneous histoplasmosis in an immunocompetent adult. Indian J Dermatol. 2012; 57:206–209.
  2. Nair SP, Vijayadharan M, et al. Primary cutaneous histoplasmosis. Indian J Dermatol Venereol Leprol. 2000; 66:151–153.
  3. Wheat LJ, Kauffman CA. Histoplasmosis. Infect Dis Clin N Am 2003; 17:1–19.
  4. Garfoot AL, Zemska O, et al. Histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation. Infect Immun. 2014; 82:393–404.
  5. Deodhar D, Frenzen F, et al. Disseminated histoplasmosis: a comparative study of the clinical features and outcome among immunocompromised and immunocompetent patients. Natl Med J India. 2013; 26:214–215.
  6. Kathuria S, Capoor MR, et al. Disseminated histoplasmosis in an apparently immunocompetent individual from north India: a case report and review. Med Mycol. 2013; 51:774–778.
  7. Panja G, Sen S. A Unique case of histoplasmosis. J Indian Med Assoc. 1954; 23:257:258.
  8. Subramaniam S, Abraham OC, et al. Disseminated histoplasmosis, J Assoc Physicians India.2005;53:185–189.
  9. Mukherjee A, Tangri R, et al. Chronic disseminated histoplasmosis bone marrow involvement in an immunocompetent patient. Indian J Hematol Blood Transfus. 2010; 26(2):65–67.
  10. Allan Jefferson Guimarães, Joshua D. Nosanchuk, et al. Diagnosis of Histoplasmosis. Braz J Microbiol. 2006; 37(1):1–13.
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