Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 23 , ISSUE 10 ( October, 2019 ) > List of Articles

CASE REPORT

Trientine-induced Rhabdomyolysis in an Adolescent with Wilson\'s Disease

Sibel Yavuz, Gokhan Tumgor, Aysun Karabay Bayazıt

Keywords : Continued renal replacement therapy, Rhabdomyolysis, Trientine

Citation Information : Yavuz S, Tumgor G, Bayazıt AK. Trientine-induced Rhabdomyolysis in an Adolescent with Wilson\'s Disease. Indian J Crit Care Med 2019; 23 (10):489-490.

DOI: 10.5005/jp-journals-10071-23271

License: CC BY-NC 4.0

Published Online: 01-10-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Drugs are very important in the etiology of nontraumatic rhabdomyolysis. Case descriptions: A 16-year-old male patient with Wilson\'s disease was admitted for myoclonic contractions. Oral trientine was started for neurological problems and tremor on the hands due to D-penicillamine 1 month ago. Patient was oligoanuric, and his creatine kinase level was 15197 U/L. Rhabdomyolysis was associated with trientine, and trientine treatment was stopped. Hemodiafiltration was performed. The patient began to urinate on the 24th day. Conclusion: This is the first pediatric patient with rhabdomyolysis induced by trientine. Drugs used should be questioned carefully in patients with rhabdomyolysis.


PDF Share
  1. Vanholder R, Sever MS, Erek E, Lameire N. J Am Soc Nephrol 2000;11:1553–1561.
  2. Ward MM. Factors predictive of acute renal failure in rabdomyolisis. Arch İntern Med 1998;148:1553–1557.
  3. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005;84:377–385.
  4. Epstein O, Sherlock S. Triethylene tetramine dihydrochloride toxicity in primary biliary cirrhosis. Gastroenterology 1980;78(6):1442–1445.
  5. Lu J. Triethylenetetramine pharmacology and its clinical applications. Mol Cancer Ther 2010;9:2458–2467.
  6. Dalvi A, Padmanaban M. Wilson's disease: Etiology, diagnosis, and treatment. Dis Mon 2014;60:450–459.
  7. European Association for Study of Liver. EASL Clinical Practice Guidelines: Wilson's disease. J Hepatol 2012;56:671–685.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.