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VOLUME 24 , ISSUE 3 ( March, 2020 ) > List of Articles


Know Thy Ulcers!!!

Citation Information : Know Thy Ulcers!!!. Indian J Crit Care Med 2020; 24 (3):153-154.

DOI: 10.5005/jp-journals-10071-23389

License: CC BY-NC 4.0

Published Online: 01-03-2020

Copyright Statement:  Copyright © 2020; The Author(s).


  1. Skillman JJ, Silen W. Acute gastroduodenal ‘stress’ ulceration: barrier disruption of varied pathogenesis? Gastroenterology 1970;59(3):478–482. DOI: 10.1016/S0016-5085(19)33734-5.
  2. Sesler JM. Stress-related mucosal disease in the intensive care unit: an update on prophylaxis. AACN Advanced Critical Care 2007;18(2):119–128. DOI: 10.1097/01.AACN.0000269254.39967.8e.
  3. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, et al. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 2015;41(5):833–845. DOI: 10.1007/s00134-015-3725-1.
  4. Eastwood GM, Litton E, Bellomo R, Bailey MJ, Festa M, Beasley RW, et al. Opinions and practice of stress ulcer prophylaxis in australian and new Zealand intensive care units. Crit Care Resusc 2014;16(3):170–174.
  5. Miano TA, Reichert MG, Houle TT, MacGregor DA, Kincaid EH, Bowton DL. Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. Chest 2009;136(2):440–447. DOI: 10.1378/chest.08-1634.
  6. Charlot M, Ahlehoff O, Norgaard ML, Jørgensen CH, Sørensen R, Abildstrøm SZ, et al. Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Ann Intern Med 2010;153(6):378–386. DOI: 10.7326/0003-4819-153-6-201009210-00005.
  7. Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ. Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 2013;41(3):693–705. DOI: 10.1097/CCM.0b013e3182758734.
  8. ASHP therapeutic guidelines on stress ulcer prophylaxis. ASHP Commission on therapeutics and approved by the ASHP board of directors on november 14, 1998. Am J Health Syst Pharm 1999;56(4):347–379. DOI: 10.1093/ajhp/56.4.347.
  9. Gupta D, Bhalotra AR, Singh R. Audit on practices of stress ulcer prophylaxis in intensive care unit patients. Indian J Criti Care Med 2020;24(3):160–167.
  10. Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, et al. Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 2018;379(23):2199–2208. DOI: 10.1056/NEJMoa1714919.
  11. Alshamsi F, Belley-cote E, Cook D, Almenawer SA, Alqahtani Z, Perri D, et al. Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 2016;20(1):120. DOI: 10.1186/s13054-016-1305-6.
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