Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 24 , ISSUE 5 ( May, 2020 ) > List of Articles


Hypopituitarism: A Rare but Often Neglected Condition

Mukta Agarwal, Rahul K Shukla

Keywords : Lactation failure, Panhypopituitarism, Recurrent hyponatremia, Secondary amenorrhea

Citation Information : Agarwal M, Shukla RK. Hypopituitarism: A Rare but Often Neglected Condition. Indian J Crit Care Med 2020; 24 (5):350-352.

DOI: 10.5005/jp-journals-10071-23422

License: CC BY-NC 4.0

Published Online: 28-07-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Pituitary insufficiency is an uncommon disorder. The most common cause is compression due to a pituitary mass. Other causes include inflammatory damage and vascular injury like postpartum pituitary apoplexy. Postpartum pituitary apoplexy, also known as Sheehan's syndrome, leads to hormonal deficiencies and causes postpartum amenorrhea, lactational failure, chronic hyponatremia, hypoglycemia, and loss of secondary sexual characters. Here we are discussing the clinical course of 15 female patients of panhypopituitarism. Most of them had a history of postpartum hemorrhage. Knowledge about this entity is essential as it is a treatable condition and ignorance could prove to be fatal.

  1. Shivaprasad C. Sheehan's syndrome: newer advances. Indian J Endocrinol Metab 2011;15(Suppl 3):S203–S207. Available from:
  2. Gei-Guardia O, Soto-Herrera E, Gei-Brealey A, Chen-Ku C. Sheehan syndrome in Costa Rica: clinical experience with 60 cases. Endocr Pract 2011;;17(3):337–344. Available from:
  3. Bunch TJ, Dunn WF, Basu A, Gosman RI. Hyponatremia and hypoglycemia in acute Sheehan's syndrome. Gynecol Endocrinol 2002;16(5):419–423. DOI: 10.1080/gye.16.5.419.423. Available from:
  4. Keleştimur F. GH deficiency and the degree of hypopituitarism. Clin Endocrinol (Oxf) 1995;42(4):443–444. DOI: 10.1111/j.1365-2265.1995.tb02659.x. Available from:
  5. Keleştimur F. Sheehan's syndrome. Pituitary 2003;6(4):181–188. DOI: 10.1023/B:PITU.0000023425.20854.8e. Available from:
  6. Huang YY, Ting MK, Hsu BR, Tsai JS. Demonstration of reserved anterior pituitary function among patients with amenorrhea after postpartum hemorrhage. Gynecol Endocrinol 2000;14(2):99–104. DOI: 10.3109/09513590009167667. Available from:
  7. Kumar N, Singh P, Kumar J, Dhanwal DK. Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome. BMJ Case Reports 2014;2014:bcr2013200991. Available from:
  8. Laway B, Allaqaband F, Kotwal S, Wani I, Banday K, Bhat M. Acute renal failure: a rare presentation of Sheehan's syndrome. Indian J Endocrinol Metab 2012;16(2):306. DOI: 10.4103/2230-8210.93777. Available from:
  9. Raina S, Jearth V, Sharma A, Sharma R, Mistry K. Postpartum pituitary apoplexy with isolated oculomotor nerve palsy: a rare medical emergency. J Neurosci Rural Pract 2015;6(4):598. DOI: 10.4103/0976-3147.165348. Available from:
  10. Zeni D, Rissetti G, Ongaratti B, Pereira-Lima JF, Rech CGSL, Oliveira M da C. Evaluation of treatment of central hypothyroidism vs primary hypothyroidism in relation to levothyroxine replacement dose. Endocr Pract 2019;25(7):663–668. DOI: 10.4158/EP-2018-0533. Available from:
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.